Results 151 to 160 of about 19,462,706 (409)
CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceSecond international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
Nature Medicine, 2023 Deirdre K. Tobias, Jordi Merino, Abrar Ahmad, Catherine E Aiken, Jamie L. Benham, D. Bodhini, Amy L. Clark, K. Colclough, Rosa Corcoy, S. Cromer, D. Duan, Jamie L. Felton, E. C. Francis, P. Gillard, Véronique Gingras, R. Gaillard, Eram Haider, A. Hughes, Jennifer M. Ikle, Laura M. Jacobsen, A. Kahkoska, J. Kettunen, R. Kreienkamp, Lee-Ling Lim, Jonna M E Männistö, Robert Massey, N. Mclennan, Rachel G. Miller, M. Morieri, J. Most, Rochelle N Naylor, Bige Ozkan, K. Patel, Scott J. Pilla, Katsiaryna Prystupa, Sridharan Raghavan, M. Rooney, M. Schön, Zhila Semnani-Azad, Magdalena Sevilla-González, Pernille Svalastoga, W. Takele, C. H. Tam, A. Thuesen, Mustafa Tosur, Amelia S. Wallace, Caroline C. Wang, Jessie J. Wong, Jennifer M. Yamamoto, K. Young, Chloé Amouyal, M. K. Andersen, M. Bonham, Mingling Chen, Feifei Cheng, T. Chikowore, Sian C. Chivers, Christoffer Clemmensen, Dana Dabelea, A. Dawed, A. Deutsch, L. Dickens, L. Dimeglio, Monika Dudenhöffer-Pfeifer, C. Evans-Molina, M. Fernández-Balsells, H. Fitipaldi, Stephanie L Fitzpatrick, S. Gitelman, M. Goodarzi, J. Grieger, M. Guasch-Ferré, Nahal Habibi, T. Hansen, Chuiguo Huang, A. Harris-Kawano, H. M. Ismail, Benjamin Hoag, Randi K. Johnson, A. Jones, R. Koivula, Aaron Leong, Gloria K. W. Leung, I. Libman, Kai Liu, S. A. Long, William L. Lowe, Robert W Morton, A. Motala, Suna Onengut-Gumuscu, J. Pankow, Maleesa M. Pathirana, S. Pazmino, Dianna Perez, John R. Petrie, Camille E. Powe, Alejandra Quinteros, Rashmi Jain, D. Ray, M. Ried-Larsen, Zeb I. Saeed, V. Santhakumar, Sarah Kanbour, Sudipa Sarkar, G. Monaco, D. Scholtens, E. Selvin, Wayne Huey-Herng Sheu, C. Speake, M. Stanislawski, N. Steenackers, A. Steck, Norbert Stefan, Julie Støy, Rachael Taylor, Sok Cin Tye, G. G. Ukke, Marzhan Urazbayeva, B. Van der Schueren, C. Vatier, J. Wentworth, Wesley Hannah, Sara L. White, Gechang Yu, Yingchai Zhang, Shao J. Zhou, J. Beltrand, Michel Polak, I. Aukrust, E. De Franco, Sarah E. Flanagan, Kristin A. Maloney, Andrew P McGovern, J. Molnes, M. Nakabuye, P. Njølstad, Hugo Pomares-Millan, Michele Provenzano, C. Saint-Martin, Cuilin Zhang, Yeyi Zhu, S. Auh, Russell J de Souza, Andrea J. Fawcett, Chandra Gruber, E. G. Mekonnen, Emily Mixter, D. Sherifali, Robert H. Eckel, J. J. Nolan, L. Philipson, Rebecca J. Brown, L. Billings, Kristen E. Boyle, T. Costacou, J. Dennis, J. C. Florez, A. Gloyn, M. Gomez, Peter A. Gottlieb, S. Greeley, Kurt J. Griffin, A. Hattersley, Irl B. Hirsch, M. Hivert, Korey K. Hood, Jami L. Josefson, S. Kwak, L. Laffel, Siew Lim, Ruth J. F. Loos, R. Ma, Chantal Mathieu, N. Mathioudakis, J. Meigs, S. Misra, Viswanathan Mohan, R. Murphy, Richard A. Oram, K. Owen, S. Ozanne, E. Pearson, W. Perng, T. Pollin, R. Pop-Busui, R. Pratley, L. Redman, M. J. Redondo, Rebecca M. Reynolds, Robert K. Semple, J. Sherr, E. Sims, A. Sweeting, T. Tuomi, M. Udler, K. Vesco, Tina Vilsbøll, R. Wagner, S. Rich, P. Franks +199 moresemanticscholar +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more source
