Results 61 to 70 of about 17,401,288 (421)

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

AI and Medicine [PDF]

open access: yesarXiv, 2019
Which part of medicine, if any, can and should be entrusted to AI, now or at some moment in the future? That both medicine and AI will continue to change goes without saying.
arxiv  

Domain-adapted large language models for classifying nuclear medicine reports [PDF]

open access: yesarXiv, 2023
With the growing use of transformer-based language models in medicine, it is unclear how well these models generalize to nuclear medicine which has domain-specific vocabulary and unique reporting styles. In this study, we evaluated the value of domain adaptation in nuclear medicine by adapting language models for the purpose of 5-point Deauville score ...
arxiv  

Redbook: 2003 [PDF]

open access: yes, 2003
Advice compiled by Boston University School of Medicine students for incoming first year students and third or fourth year students preparing for clinical ...
Boston University School of Medicine
core  

Systematic review of pain medicine content, teaching, and assessment in medical school curricula internationally [PDF]

open access: yes, 2018
Introduction: Pain management is a major health care challenge in terms of the significant prevalence of pain and the negative consequences of poor management.
Bate, Frank   +5 more
core   +3 more sources

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

open access: yesFEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin   +2 more
wiley   +1 more source

Medicine and Science in Sports and Exercise

open access: yes, 1981
ض;;;عب ى;;;لع ة;;;بكرملا تابيرد;;;تلا ريثا;;;ت فر;;;عتلا ى;;;لإ ث;;;حبلا اذ;;;ھ فد;;;ھي يوتسملاو ةيندبلا و ةيئايميكويبلا تاريغتملا ةحابسل يمقرلا 50 م ي;لع فحز نطبلا وذ ي;بيرجتلا ميم;صتلا مادخت;ساب ي;بيرجتلا جھنملا ثحابلا مدختسإ دقو ، ةدحاو ةيبيرجت ...
Sung Gyoo Park
semanticscholar   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

American College of Sports Medicine position stand. Progression models in resistance training for healthy adults.

open access: yesMedicine & Science in Sports & Exercise, 2011
In order to stimulate further adaptation toward specific training goals, progressive resistance training (RT) protocols are necessary. The optimal characteristics of strength-specific programs include the use of concentric (CON), eccentric (ECC), and ...
Position Stand
semanticscholar   +1 more source

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