Results 181 to 190 of about 9,199,416 (314)

Turning precision medicine into reality with statistics and data-driven decision making across pharmaceutical development. [PDF]

Commun Med (Lond)
Desachy G, Köchert K, Krämer N, Kubiak R, Biomarkers European Special Interest Group.   +4 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Coaching and Individualized Learning in Competency-Based Medical Education: Framework Development and Research Priorities. [PDF]

AEM Educ Train
Mand SK, Wolff M, Zamignani N, Williams SR, Santen SA, Scott KR, Garrett A, Brown C, Kim JG, Dorfsman ML, Caretta-Weyer H, Branzetti J.   +11 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Organizational and Systems-Based Framework to Guide a Departmental Approach to Academic and Leadership Advancement for Women in Emergency Medicine. [PDF]

J Am Coll Emerg Physicians Open
Zachrison KS, Kapanadze M, James D, Al Jalbout N, Cash RE, Chua WJ, Dobiesz V, Egan DJ, Nelson EL, Pham P, Temin E, Samuels-Kalow ME.   +11 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Continuity of care should be Dr Ian McWhinney's lasting legacy: Part 4 of the 10-part series, "Foundations for tomorrow". [PDF]

Can Fam Physician
Heath I.
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

INFORMATION AND TELECOMMUNICATION TECHNOLOGIES IN ACTIVITIES OF SERVICE FOR DISASTER MEDICINE OF MINISTRY OF HEALTH OF RUSSIA

Медицина катастроф, 2019
Baranova N.N., Bobiy B.V., Goncharov S.F., Nazarenko G.I., Odintsov N.I.   +4 more
doaj   +1 more source

National Assessment of Emergency, Intensive Care, and Anesthesia Physician Distribution in Saudi Arabia, 2023: Implications for Emergency Care Access. [PDF]

Emerg Med Int
Kattan WM.
europepmc   +1 more source