Results 191 to 200 of about 24,092,998 (355)

Fake medicines: fighting on all fronts [PDF]

The Lancet Respiratory Medicine, 2018
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Prevalence and risk factors of difficult-to-treat axial spondyloarthritis: Real-life evidence from the BioSTaR database. [PDF]

Clin Rheumatol
Bodur H, Ataman Ş, Yurdakul FG, Gürer G, Akgün K, İnceoğlu LA, Sunar İ, Akgül Ö, Sezer İ, Çapkın E, Rezvani A, Yağcı İ, Duruöz MT, Çay HF, Çevik R, Göğüş F, Kamanlı A, Ecesoy H, Güler T, Şahin N, Cengiz G, Melikoğlu MA.   +21 more
europepmc   +1 more source

Prescribed Renoprotective Chinese Herbal Medicines Were Associated with a Lower Risk of All‐Cause and Disease‐Specific Mortality among Patients with Chronic Kidney Disease: A Population‐Based Follow‐Up Study in Taiwan [PDF]

, 2017
Chuan-Fa Hsieh, Huan‐Cheng Chang, Song‐Lih Huang, Chien‐Lung Chen, Wei‐Ta Chen, Chen-Chang Yang   +5 more
openalex   +1 more source

Rudolf Virchow, poverty and global health: from “politics as medicine on a grand scale” to “health in all policies”

, 2021
Klaus W. Lange
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive Medicine Promotional Activity of Pharmaceutical Industry All Over the Globe: Who Will Do the Highly Risky Job to Defy the Monstrous Financial Tyrant?

, 2020
Mainul Haque
openalex   +2 more sources

Estimated Versus Observed Expenditure Associated with Medicines Recommended by the All Wales Medicines Strategy Group [PDF]

, 2019
Stuart Keeping, Paul Deslandes, Kathryn E. Haines, Philip A. Routledge   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Awareness of Primary Biliary Cholangitis Among Turkish Physicians: A Cross-Sectional, Multicenter, Web-Based Survey. [PDF]

J Clin Med
Eruzun H, Gronbaek H.
europepmc   +1 more source