Results 41 to 50 of about 27,292,570 (391)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Integrative concept of homeostasis: translating physiology into medicine [PDF]
, 2011 To truly understand living systems they must be viewed as a whole. In order to achieve this and to come to some law to which living systems obey, data obtained on cells, tissues and organs should be integrated.
Ivan Spasojevic, Ivan Spasojevic
core +3 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
"A manager in the minds of doctors" : a comparison of new modes of control in European hospitals [PDF]
, 2013 Background: Hospital governance increasingly combines management and professional self-governance. This article maps the new emergent modes of control in a comparative perspective and aims to better understand the relationship between medicine and ...
Burau, Viola +6 more
core +4 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Allopathic Medicine’s Influence on Indigenous Peoples in the Kumaon Region of India [PDF]
, 2018 This paper focuses on the use of western medicine in the Kumaon region of Uttarakhand, India. The goal of this research is to understand which healing practices are preferable in rural villages.
Blum, Eliana M
core +1 more source
Reumatismo, 2023 Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by macrophages and cytotoxic T cells with aberrant activation. The primary (genetic) form, which is caused by mutations that affect lymphocyte cytotoxicity and immune ...
P. Sukhadiya +6 more
doaj +1 more source
Occupational medicine for one and all. [PDF]
Occupational and Environmental Medicine, 1991 In the 1930s in Britain, industrial medicine was a clinical discipline, the main purposes of which were to diagnose disability in applicants for work, to identify industrial disease in the dangerous trades, and to provide first aid treatment for those injured or taken sick in the workplace.
openaire +3 more sources
The era of modern medicine: implants and all [PDF]
Frontline Gastroenterology, 2012 Modern medicine is awash with technological advance. Though the last three decades have witnessed countless pharmacological successes, the pace of novel drug development has slowed down. Since the dawn of the new century, medicine has embraced technological changes with a resultant increase in implantable devices.
Rakesh Sharma, Kaushik Guha
openaire +3 more sources
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source