Results 61 to 70 of about 5,062,841 (308)

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

The development, evaluation, performance, and validation of micro-PCR and extractor for the quantification of HIV-1 &-2 RNA

Scientific Reports
HIV infection has been a global public health threat and overall reported ~ 40 million deaths. Acquired immunodeficiency syndrome (AIDS) is attributed to the retroviruses (HIV-1/2), disseminated through various body fluids.
Shyam Prakash, Ram Aasarey, Priyatma, Meenakshi Sharma, Shahid Khan, Medha   +5 more
doaj   +1 more source

Pentraxin-3 as a novel biomarker in predicting outcomes of nosocomial pneumonia: a prospective observational study

Monaldi Archives for Chest Disease
Pneumonia, among all nosocomial infections, is known for its dismal prognosis, imposing substantial morbidity and mortality. While the diagnostic performance of various blood biomarkers has undergone scrutiny, their prognostic implications remain ...
Isha Garg, Nishant Kumar Chauhan, Harsh Vardhan, Shrimanjunath Sankanagoudar, Naveen Dutt, Gopal Durgeshwar, Hariharan Iyer, Nikhil Kothari, Ravisekhar Gadepalli, Deepak Kumar   +9 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Nordic walking training and nutritional supplementation in pre-frail older Indians: an open-labelled experimental pre-test and post-test pilot study to develop intervention model

BMC Geriatrics, 2018
Background Identifying and treating people in a pre-frail state may be an effective way to prevent or delay frailty and preserve their functional capacity.
Prasun Chatterjee, Prakash Kumar, Ramesh Kandel, Ruchika Madan, Meenakshi Tyagi, Deepa Anil Kumar, Maroof Ahmad Khan, Gaurav Desai, Preeti Chaudhary, Shyama Gupta, Kanika Grover, Aparajit Ballav Dey   +11 more
doaj   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Validation of the Indian (Hindi) version of the life-space assessment scale among community-dwelling older adults: a multicentric cross-sectional study

BMC Geriatrics
Background The Life-Space Assessment (LSA) is an instrument that measures mobility in older adults as they reach different areas, defined as life-spaces extending from home to beyond towns or regions.
Durgesh Prasad Sahoo, Soumya Swaroop Sahoo, Santosh Kumar Nirala, Rama Shankar Rath, Neeraj Agarwal, Meely Panda, Rakesh Kakkar, Sanjay Pandey, C M Singh, Hari Shanker Joshi, Bhola Nath   +10 more
doaj   +1 more source

Utility of chest ultrasound in the diagnosis of ventilator-associated pneumonia in the critical care unit of a tertiary care center: a prospective observational study

Monaldi Archives for Chest Disease
Ventilator-associated pneumonia (VAP) is a type of nosocomial pneumonia developing in patients who are mechanically ventilated for ≥48 hours. Lung ultrasound (LUS) has been shown to be useful in evaluating various pathologic pulmonary conditions.
Avinash Babu, Aditi Joshi, Amartya Chakraborti, Pradeep Bajad, Ramniwas Jalendra, Nishant Chauhan, Naveen Dutt   +6 more
doaj   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source