Results 91 to 100 of about 6,719,287 (354)

Observations of evidence-based medicine in general practice

open access: yesPerspectives on Medical Education, 2013
No objective measures are available for assessing the practice of evidence-based medicine (EBM) in general practitioner (GP) trainees, as there is no description of the EBM behaviour that is expected from trainees.
Sandra E. Zwolsman   +2 more
doaj   +1 more source

Aspects of general medicine [PDF]

open access: yes, 2008
Horizons in Medicine is a series produced annually by the Royal College of Physicians. Volume 19 is based on their Advanced Medicine Conference held in 2007 and offers updates on a wide range of topics in clinical medicine.
Kumana, CR
core  

IrGO: Iranian traditional medicine General Ontology and knowledge base. [PDF]

open access: yesJ Biomed Semantics, 2021
Naghizadeh A   +9 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

A Classification Method for General Medicine Physicians to Advance Field Research in Japan

open access: yesInternational Journal of General Medicine
Masaki Tago,1 Risa Hirata,1 Kiyoshi Shikino,2,3 Takashi Watari,4 Hiromizu Takahashi,5 Tomoyo Nishi,1 Yosuke Sasaki,6 Taro Shimizu7 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of Community-Oriented Medical Education,
Tago M   +7 more
doaj  

The Liverpool Care Pathway [PDF]

open access: yes, 2013
For many practising doctors, especially in general practice or in general internal medicine, decisions at the end of life are often some of the most difficult.
Saunders, John
core  

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