Results 121 to 130 of about 6,719,287 (354)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Representing disease courses: An application of the Neurological Disease Ontology to Multiple Sclerosis Typology [PDF]

open access: yes, 2013
The Neurological Disease Ontology (ND) is being developed to provide a comprehensive framework for the representation of neurological diseases (Diehl et al., 2013).
Cox, Alexander P.   +3 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

kurz und kn@pp news : Nr. 8 [engl. Fassung] [PDF]

open access: yes, 2007
* Advance Notice: 1st Frankfurt General Practice Day * Tips on how to avoid errors * STERN-Leading article on high blood pressure in cooperation with the Institute * 2nd part of DEGAM chronic heart failure guideline - long version * Launch of the ...

core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The content of general practice in Malta : a pilot study comparing health centre and private practice in Malta with each other and with general practice (as reported for other countries) [PDF]

open access: yes, 1989
The effective planning of a system and the training of personnel to run it requires accurate data regarding the use to be made of the system. For a health care system such data, apart from actual numbers of patients, will include age/sex distribution ...
Agius Muscat, Hugo, Carabott, Paul
core  

Generic Medicines and Branded Medicines

open access: yes
Around the world, generic prescriptions are a widely acknowledged notion. However, due to issues like unavailability and mistrust regarding the product's quality, it hasn't become as popular in India. On the other hand, the West Bengal government in India launched "fair price medicine shop" (FPMS) exclusive generic drug stores within government ...
Aarcha M R, Fathima K K
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

The Population Problem: A Third World Reaction [PDF]

open access: yes, 1976
Dr. Mascarenhas is Consultant in Community Health and Family Planning at the Family Welfare Center in Bangalore, India. Until April, 1975, she was Head of the Department of Preventive and Social Medicine at St.
Mascarenhas, Marie M.
core   +1 more source

Home - About - Disclaimer - Privacy