Results 161 to 170 of about 4,061,969 (303)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Evidence-based medicine

open access: yes, 2008
Title from Web page (viewed Oct. 7, 2008).; "September 18, 2008."; Discusses what evidence-based medicine is; who determines when medicine is evidence-based; how these decisions are translated into medical practice and health policy; obstacles health ...
Spigel, Saul.
core  

Editorial: Insights in General Cardiovascular Medicine: 2021

open access: yesFrontiers in Cardiovascular Medicine, 2022
Lijun Wang   +8 more
doaj   +1 more source

How far on the road? The role of family medicine/general practice in 10 Central and Eastern European countries: A mixed-method study. [PDF]

open access: yesEur J Gen Pract
Oleszczyk M   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Wellcome Witnesses to Twentieth Century Medicine: Volume 2

open access: yes, 1998
Annotated and edited transcripts of 4 Witness Seminars. Introduction by E M Tansey. First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998. ©The Trustee of the Wellcome Trust, London, 1998.All volumes are freely available online
Christie, DA, Reynolds, LA, Tansey, EM
core  

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