Results 201 to 210 of about 3,953,028 (257)

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Correction to: Preoperative phase angle and postoperative complications in Crohn's disease patients undergoing ileocolic resection: a retrospective cohort study. [PDF]

Int J Colorectal Dis
Qi W, Liu H, Liang H, Liu W, Ye L, Cao Q, Ge X, Zhou W.   +7 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Primary Care Career Perceptions: Comparing Temperament and Character Inventory Profiles of Medical Students with General Practitioners. [PDF]

Int J Environ Res Public Health
Nánási A, Rekenyi V, Szepesi CI, Kovács E, Horváth N, Kun A, Kolozsvári LR.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Preoperative Risk Evaluation for Cancer Treatment (PREdiCT): protocol for an international cohort study evaluating a trimodal screening tool to predict outcomes following gastrointestinal cancer surgery. [PDF]

BMJ Open
Reeves J, Koh C, Alexander K, Solomon M, Karunaratne S, Petridis A, Carey S, Dhillon H, White K, Pillinger N, Gillis C, Hirst N, Shadid Z, Rahman MI, Boden I, Mahoney A, Woodfield J, Vagg D, De Boer HD, Sutton P, Pereira L, Drummond-Lage AP, Mcloughlin S, Alvarez A, Pirie K, Hii MW, Suliman A, Uçaner B, Schizas D, Nassim K, Albatool R, Ali K, Triantafyllou T, Styliana A, Merlini I, Van Daele E, Mulita F, Bell M, Martinez-Palli G, Koch C, Falconi M, Garmanova T, Deng N, Tirelli F, Lubbers T, Chwat C, Costales A, Hanna NM, Petrova A, Khamees A, Beard D, Granger CL, PREdiCT Study Investigators, Steffens D.   +53 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Development and validation of a clinical scoring system for the prediction of methotrexate treatment response in rheumatoid arthritis patients: a multicenter real-world study. [PDF]

Ther Adv Musculoskelet Dis
Hidayat R, Fauzia F, Kusumo Wibowo SA, Ariane A, Partan RU, Muthia P, Warlisti IV, Suntoko B, Pratama MZ, Wahono CS, Rahmawati LD, Kurniari PK, Utomo AK, Najirman N, Kurniawan E, Werdiningsih Y, Pango F, Dhifanra MA, Audrey J, Parlindungan F.   +19 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source