Results 211 to 220 of about 6,257,987 (347)
In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock +8 more
wiley +1 more source
A Validated Model to Predict Severe Weight Loss in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Severe weight loss in amyotrophic lateral sclerosis (ALS) is common, multifactorial, and associated with shortened survival. Using longitudinal weight data from over 6000 patients with ALS across three cohorts, we built an accelerated failure time model to predict the risk of future severe (≥ 10%) weight loss using five single‐timepoint ...
David G. Lester +4 more
wiley +1 more source
La investigación científica en residentes de Medicina General Integral
Revista Médica ElectrónicaLa investigación científica en residentes de Medicina General Integral se desarrolla de manera gradual, aspecto que no puede verse aislado, sino insertada en problemáticas sociales o laborales.
Raidel González Rodríguez +1 more
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinal muscular atrophy (SMA) significantly impacts motor function. This study aimed to assess the persistent burden and unmet needs among currently treated patients with SMA and their caregivers. Methods Two complementary web‐based surveys were distributed in August 2024 among patients with SMA and their caregivers.
Julie A. Parsons +8 more
wiley +1 more source
Training in the speciality of General and Family Medicine in Angola: A cross-sectional study. [PDF]
Afr J Prim Health Care Fam MedDa Silva Fernandes CTL +3 more
europepmc +1 more source
Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the utility of smartwatch and smartphone‐based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In the electronic monitoring of disease activity in patients with CIDP (EMDA‐CIDP) trial, we performed a prospective ...
Lars Masanneck +15 more
wiley +1 more source
International Journal of General MedicineRisa Hirata,1 Masaki Tago,1 Kiyoshi Shikino,2,3 Takashi Watari,4 Hiromizu Takahashi,5 Yosuke Sasaki,6 Taro Shimizu7 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of General Medicine, Chiba University Hospital, Chiba,
Hirata R +6 more
doaj