Results 41 to 50 of about 6,393,089 (340)

New Horizons in Psychiatry [PDF]

open access: yes, 1971
Psychiatrists have long held that there should be more psychiatry in general medicine, and the nonpsychiatric physicians have said that there should be much more medicine in psychiatry.
Mathis, James L.
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Application of Kampo Medicines for Treatment of General Fatigue Due to Long COVID

open access: yesMedicina, 2022
Evidence regarding treatment for the acute phase of COVID-19 has been accumulating, but specific treatment for long COVID/post-COVID-19 condition has not yet been established.
Kazuki Tokumasu   +12 more
doaj   +1 more source

"It isn't just consultants that need a BSc": student experiences of an Intercalated BSc [PDF]

open access: yes, 2005
More medical schools are moving towards a compulsory intercalated BSc. These courses have not traditionally been aimed at those students interested in general practice and have tended to have limited clinical relevance.
Jones, M., Lloyd, M., Singh, S.
core  

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Chest pain as a diagnostic dilemma in community-acquired pneumonia – A clinical perspective

open access: yesAsian Journal of Medical Sciences
Pneumonia that develops outside of health facility is called community-acquired pneumonia (CAP). A diagnosis of CAP requires the patient to present with leukocytosis, fever, dyspnea, cough, and other clinical syndromes, as well as an infiltrate seen upon
Ranjan Kumar Singh
doaj   +1 more source

Aspects of general medicine [PDF]

open access: yes, 2008
Horizons in Medicine is a series produced annually by the Royal College of Physicians. Volume 19 is based on their Advanced Medicine Conference held in 2007 and offers updates on a wide range of topics in clinical medicine.
Kumana, CR
core  

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

The future of general medicine [PDF]

open access: yesClinical Medicine, 2014
It is a truth universally acknowledged that there is a problem with general medicine. Physicians have become increasingly specialised over the past 30 years or so, and specialist care has produced increasingly better outcomes for some patients. The patients left behind are looked after by general medicine, where demand is increasing, operational ...
openaire   +2 more sources

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