Results 41 to 50 of about 6,504,161 (307)

Chest pain as a diagnostic dilemma in community-acquired pneumonia – A clinical perspective

Asian Journal of Medical Sciences
Pneumonia that develops outside of health facility is called community-acquired pneumonia (CAP). A diagnosis of CAP requires the patient to present with leukocytosis, fever, dyspnea, cough, and other clinical syndromes, as well as an infiltrate seen upon
Ranjan Kumar Singh
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Systolic blood pressure levels and mortality in Australian medical inpatients

The Journal of Clinical Hypertension, 2023
The epidemiology of elevations in blood pressure is incompletely characterized, particularly in Australia. Given the lack of evidence regarding the frequency and the optimal management of in‐hospital hypertension, the authors performed a multicenter ...
Jin Nuo Joan Tsang, Stephen Bacchi, Joshua G. Kovoor, Aashray K. Gupta, Brandon Stretton, Samuel Gluck, Toby Gilbert, Yogesh Sharma, Richard Woodman, Arduino A. Mangoni   +9 more
doaj   +1 more source

Oral characteristics of Trisomy 8 and monosomy 18: a case report [PDF]

, 2011
Several reports described various mosaic chromosomal syndromes characterized by alterations originated by either an excess or deficit in the number of chromosomes.
Campus, Guglielmo Giuseppe, Lugliè, Pietrina Francesca, Sale, Silvana, Spano, Giovanni   +3 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Erratum

International Journal of General Medicine, 2011
Shehata GA, Elserogy YM, Ahmad HEK, Abdel-Kareem MI, Al-kabeer AM, Rayan MM, Abd El-Baky MES. Multimodal neurophysiological and psychometric evaluation among patients with systemic lupus erythematosus. International Journal of General Medicine.
Shehata GA, Elserogy YM, Ahmad HEK, Abdel-Kareem MI, Al-kabeer AM, Rayan MM, Abd El-Baky MES   +6 more
doaj  

Rural Doctor Conversation [PDF]

, 2010
South Asia in general, and India specifically, are regions with immense diversity in culture and language. Because of this conversations about medicine between doctors and patients takes different forms from one region to another. This is especially true
Joshi, Himanshu, Nik Ilieva, Gabriela, Ranjan, Rakesh, Shankar, Jishnu   +3 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Application Effect of Traditional Chinese Medicine Nursing on General Anesthesia Combined with Epidural Anesthesia and Electric Resection for the Treatment of Bladder Cancer and Its Influence on Tumor Markers [PDF]

, 2022
Yan Wu, Zhenna Zhang, Yangfan Liu, Guangwen Shi, Xuehai Ding   +4 more
openalex   +1 more source