Results 191 to 200 of about 2,087,343 (250)

What do youth need to know about puberty? A scoping review protocol to identify puberty education competencies. [PDF]

PLoS One
Brault MA, Singh N, Kakkad N, Peskin M, Betori A, Laynor G, Naiser E.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Synthesis of the Best Evidence for Rhubarb Administration in the Treatment of Acute Pancreatitis in China. [PDF]

J Multidiscip Healthc
Han LJ, Pan XW, Zhu J, Qin JY, He HL, Chen H, Wang D, Zhuang HR, Ma LL.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Publication and Retraction Activity in the Field of Extracorporeal Membrane Oxygenation: Origins, Concerns, and Perspectives. [PDF]

J Korean Med Sci
Permenov BA, Zimba O, Suigenbayev D, Kocyigit BF.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Erratum to: <i>PPP1R12A</i> mutation leads to different genders of twinning: a case report and literature review. [PDF]

Transl Pediatr
Editorial Office.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Sociodemographic factors associated with the utilisation of specialist palliative care in individuals with end-stage kidney disease: protocol for a scoping review. [PDF]

BMJ Open
Jameson E, Brown PP, Bruni A, Wassef M, Chang R, Milne K, Berry J, Bonares M.   +7 more
europepmc   +1 more source

Outcomes of the SAEM Competency-Based Medical Education Consensus Conference: Challenges and Opportunities in Implementing CBME. [PDF]

AEM Educ Train
Hopson LR, Caretta-Weyer H, Ankel F, Cooney R, Fant A, Hall AK, Jacobson J, Kropf CW, Kulkarmi M, Lall MD, Landry A, Manella H, Parker C, Roszczynialski KN, Tanski M, Joarder A, Regan L.   +16 more
europepmc   +1 more source