Results 161 to 170 of about 1,652,787 (364)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Medicines policy, access and use in Mexico: a systematic literature review 2000–2022

open access: yesDrugs in Context
Background: Research on medicines access and use is heterogeneous and can be challenging for decision- makers to interpret. Pharmaceutical policy is an additional component for study and is the foundation for the promotion of access and use of medicines.
Laura Cristina Vargas López   +3 more
doaj   +1 more source

The new licencing examination for human medicine: from concept to implementation

open access: diamond, 2013
Sissel Guttormsen   +7 more
openalex   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Network medicines™

open access: yesJournal of Translational Medicine, 2023
openaire   +3 more sources

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