Results 171 to 180 of about 418,657 (266)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Resources consumption and environmental impacts of the DYNAMIC digital health intervention aimed at improving quality of care for sick children in Tanzania: a life cycle assessment. [PDF]

Front Digit Health
Karlen M, Emery N, Tan R, Kavishe G, Agrea P, Renggli S, Kulinkina AV, Luwanda L, Isdory G, Mtebene I, Mangu C, Castella PS, Bengoa X, D'Acremont V.   +13 more
europepmc   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Evaluation of the Quality Decision-Making Practices Utilized by the Zambia Medicines Regulatory Authority Technical Committees. [PDF]

Pharmaceut Med
Chisha CS, Siyanga M, Leigh S, Lara J, Walker S.   +4 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Do publicly supported generic pharmacies improve financial risk protection? Findings from a nationally representative cross-sectional survey in India. [PDF]

BMJ Open
Purohit N, Goyal A, Jyani G, Soman B, Kar SS, Verma R, Singh K, Albert S, Patel P, Rana SK, Kumar S, Biswal SB, Prinja S.   +12 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Rational use of expensive medicines in the Netherlands: strategies to improve effectiveness and reduce burden on patients and society - a narrative review. [PDF]

BMC Med
Penninx BMF, Tas SW, Timmers L, van de Kar NCAJ, Huisman A, van den Berg D, van Kempen ZLE, Hollak CEM.   +7 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Medication Adherence, Treatment Attitudes, and Beliefs About Medicines in Romanian Psychiatric Patients: A Cross-Sectional Study. [PDF]

Diseases
Vasile AI, Arsene A, Petru IR.
europepmc   +1 more source