Results 191 to 200 of about 607,787 (304)

Illegal medicines observed in the EU

The World Health Organisation distinguishes two categories of illegal medicines, namely substandard and falsified medicines. The latter group can however not be considered as a homogeneous group and could further be subdivided in unauthorized and ...
E. Deconinck
core  

Fortifying essential medicines supply chains in Sub-Saharan Africa - the curious cases of Kenya and Uganda. [PDF]

Glob Health Action
Kludze M, Hussein M.
europepmc   +1 more source

Disaster Medicine — Humanitarian Medicine [PDF]

Prehospital and Disaster Medicine, 1998
openaire   +2 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Availability and reimbursement of fixed-dose combination medicines for hypertension treatment in Central and Eastern Europe. [PDF]

Front Pharmacol
Nowak R, Holko P, Hoxha I, Savova A, Draganić P, Skoupa J, Männik A, Kaló Z, Praskilevics A, Garuoliene K, Shuturkova L, Chitan E, Duborija-Kovacevic N, Owca M, Bianchi-Manaila I, Stefanovic N, Tesar T, Ágh T, Kawalec P.   +18 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

A Narrative Review of Medication Optimisation in Older Adults with Polypharmacy: From Structured Medication Review to AI-Enabled Medication Safety. [PDF]

Healthcare (Basel)
Aro R, Wojszel ZB, Duez P, Lecron F, Patris S.   +4 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Service availability and readiness of primary healthcare facilities in Cambodia (2020-2025): a systematic review. [PDF]

BMJ Public Health
Yem S, Tun S, Kem S.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source