Results 211 to 220 of about 3,617,077 (391)
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Global mechanisms to improve affordability of high-priced medicines: the role of the WHO model lists of essential medicines. [PDF]
Jenei K.
europepmc +1 more source
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Pensando o processo saúde doença: a que responde o modelo biomédico?
Com o propósito de efetuar uma crítica ao modelo biomédico, mecanicista, hegemônico na doutrina e prática que informa a medicina na atualidade, o texto parte de uma síntese histórico-evolutiva que contempla a apresentaçao das idéias e personagens chave ...
José Augusto C. Barros
doaj
Use of medications with pharmacogenomic guidelines and adverse outcomes in hospitalised older patients: a retrospective cross-sectional study. [PDF]
David V +8 more
europepmc +1 more source
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source

