Results 51 to 60 of about 40,662 (242)

Intestinal absorption and lymphatic transport of cholesterol in the rat: influence of the fatty acid chain length of the carrier triglyceride

Journal of Lipid Research, 1969
This paper deals with the effect of the fatty acid chain length of dietary triglyceride on the intestinal uptake and lymphatic transport of exogenous and endogenous cholesterol in the rat.
Christer Sylvén, Bengt Borgström
doaj   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

The impact of lipid-rich nutrition on ketogenesis and muscle weakness in sepsis

Intensive Care Medicine Experimental
Background Administration of ketone bodies attenuated the severity of sepsis-induced muscle weakness in preclinical studies. Whether lipid-rich emulsions may likewise mitigate such muscle weakness by stimulating the endogenous ketogenic capacity remains ...
Caroline Lauwers, Jan Gunst, Soraya El Dawy, Sarah Derde, Lies Pauwels, Inge Derese, Sarah Vander Perre, Greet Van den Berghe, Michael P. Casaer, Lies Langouche   +9 more
doaj   +1 more source

中链甘油三酯中甘油二酯的分离与结构鉴定Isolation and identification of diglycerides from medium-chain triglycerides

Zhongguo youzhi
旨在阐明中链甘油三酯产品中的主要副产物甘油二酯类杂质的化学成分，以中链甘油三酯为原料，通过硅胶柱层析和半制备高效液相色谱法分离其中的甘油二酯，并通过核磁谱、质谱、红外光谱、紫外光谱和气相色谱对甘油二酯的结构进行鉴定。结果表明：从中链甘油三酯中分离出6种甘油二酯（DG-1~DG-6），结构依次被鉴定为1，3-二辛酸甘油二酯、1，2-二辛酸甘油二酯、1，3-辛酸癸酸甘油二酯、1，2-辛酸癸酸甘油二酯、1,3-二癸酸甘油二酯、1,2-二癸酸甘油二酯 ...
王国财，唐顺之，袁诚，李继荣，牟肖男，许文东王国财，唐顺之，袁诚，李继荣，牟肖男，许文东
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

The usefulness of dietary medium-chain triglycerides in body weight control: fact or fancy?

Journal of Lipid Research, 1996
Compared to long-chain triglycerides (LCT), medium-chain triglycerides (MCT) display some specific physico-chemical, and biological characteristics. Thus, MCT are currently used in clinical nutrition as energy-yielding substrates, and have been advocated
A C Bach, Y Ingenbleek, A Frey
doaj   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Effects of Medium-Chain Versus Medium- and Long-Chain Triglycerides, Combined with Carotenoids, in a High-Fat Diet on Obese Mice

Foods
While medium-chain triglycerides (MCTs), medium- and long-chain triglycerides (MLCTs), and carotenoids individually possess anti-obesity properties, the synergistic metabolic regulatory effects of their combined intervention remain under-investigated ...
Ruihong Ge, Keyu Tu, Jinyang Li, Liang Wu, Yongjian Ge, Yongkang Niu, Shiyu Chen, Qinglong Wu, Ruozhen Wang, Shiqing Chen, Yoong Junhao, Hui Wang   +11 more
doaj   +1 more source