Results 41 to 50 of about 5,028 (304)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Lattice structures and mechanical properties of FeCrNi medium-entropy alloy prepared by selective laser melting

Cailiao gongcheng
Metal lattice structural materials are widely used in aerospace, automotive industry, and other fields due to their advantages of lightweight, high specific strength, energy absorption, and porosity.
SUN Chi, WANG Jian, HE He, QIN Dongyang, CAO Yuankui, FU Ao, LIU Bin   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Microstructure and mechanical properties of Al-Co-Fe-Ni eutectic medium-entropy-alloys

Next Materials
The Al-Co-Fe-Ni eutectic medium-entropy-alloys (EMEAs) were designed to study its microstructure and mechanical properties. It was found that among these medium-entropy alloys, the AlCoFe1.5Ni2.0 alloy has the mixed eutectic structures of CoFeNi-type FCC
Wenxuan Li, Longtu Yang, Xilin Gan, Yong Dong   +3 more
doaj   +1 more source

Hierarchically heterogeneous microstructure and mechanical behavior of the multi-materials prepared by powder severe plastic deformation

Materials Research Letters, 2023
A heterostructuring strategy is an effective approach for abiding problems referred to as the strength-ductility trade-off. However, tailoring the heterostructure is an arduous problem.
Sujung Son, Jungwan Lee, Peyman Asghari-Rad, Rae Eon Kim, Hyojin Park, Jae-il Jang, Wen Chen, Yoon-Uk Heo, Hyoung Seop Kim   +8 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Exceptional damage-tolerance of a medium-entropy alloy CrCoNi at cryogenic temperatures

Nature Communications, 2016
High-entropy alloys derive their properties from being multi-element systems that can crystallize as a single phase. Here, the authors examine a medium-entropy alloy, CrCoNi, which displays strength-toughness properties exceeding those of high-entropy ...
Bernd Gludovatz, Anton Hohenwarter, Keli V. S. Thurston, Hongbin Bei, Zhenggang Wu, Easo P. George, Robert O. Ritchie   +6 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A Study on the Mechanical Behavior and Deformation Mechanism of the Aged Ni2CoCr0.5Si0.3Al0.1Ti0.1 Medium Entropy Alloy

Taiyuan Ligong Daxue xuebao
Purposes A novel type of Ni2CoCr0.5Si0.3Al0.1Ti0.1 medium entropy alloy is designed in this work. Methods Trace amounts of Si, Al, and Ti elements are added to the non-equiatomic ratio NiCoCr-based medium entropy alloy, and dispersed coherent L12 phase ...
LUO Shunhui, CHANG Hui, WANG Qiang, ZHANG Jiaxin, ZHANG Tuanwei, WANG Zhihua   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source