Results 111 to 120 of about 468,311 (320)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

State estimation applied to active distribution networks with minimal measurements [PDF]

, 2005
Traditionally, state estimation is applied to transmission networks to improve security and redundancy of the measurement system. This paper describes the application of state estimation to distribution networks in order to extend the observability of ...
Jenkins, Nick, Thornley, Vincent, White, Sara   +2 more
core  

The Alternate Arm Converter: A New Hybrid Multilevel Converter With DC-Fault Blocking Capability

, 2013
This paper explains the working principles, supported by simulation results, of a new converter topology intended for HVDC applications, called the alternate arm converter (AAC).
Critchley, R, Crookes, W, Green, TC, Hassan, F, Merlin, MMC, Mitcheson, PD, Trainer, DR   +6 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Exploring the Viability of Local Electricity Markets for Managing Congestion in Spanish Distribution Networks

Energies
This article presents the methodology and results developed as part of the Integration of Energy Resources through Local Electricity Markets (IREMEL) project, whose aim is to assess the capability of flexibility markets to manage eventual distribution ...
Fernando García-Muñoz, Mariana Jiménez-Martínez, Josh Eichman, Cristina Corchero, Gabriela Benveniste   +4 more
doaj   +1 more source

Planning and Performance Challenges in Power Line Communications Networks for Smart Grids

International Journal of Distributed Sensor Networks, 2016
The Smart Grid represents a revolution especially at distribution and customer levels, bringing monitoring and control capabilities, traditionally available up to the primary substations, down to the secondary substations, and beyond. Machine-to-Machine (
Miguel Seijo, Gregorio López, Javier Matanza, José Ignacio Moreno   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Multilevel Converters: An Enabling Technology for High-Power Applications [PDF]

, 2009
| Multilevel converters are considered today as the state-of-the-art power-conversion systems for high-power and power-quality demanding applications.
García Franquelo, Leopoldo, Kouro, Samir, León Galván, José Ignacio, Martín Prats, María de los Ángeles, Portillo Guisado, Ramón Carlos, Pérez, Marcelo, Rodríguez, José   +6 more
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source