Results 91 to 100 of about 3,143,759 (269)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
This is a pre-print of a chapter for the Encyclopedia of Astrophysics (edited by I. Mandel, section editor S.
Chen, Hsiao-Wen, Zahedy, Fakhri S.
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
NORMATIVE LEGAL FRAMEWORK AND PRACTICE OF STATE PLANNING IN RUSSIAN FEDERATION
Модернизация, инновация, развитие, 2016 Today, Russia is not secured by the principal – the legal basis for the formation of a unified system of planning and links between federal and regional aspects, and the lack of systematic approach to planning at the state level affects the pace of ...
O. O. Smirnova
doaj
Вестник Северо-Кавказского федерального университетаIntroduction. Among the many financial indicators for assessing the condition of assets, it is important to highlight the indicator of property mobility, which determines the share of tangible assets in their total value.Goal.
M. V. Galazova
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Pramana, 2006 In these lectures I first give a motivation for investigations of in-medium properties of hadrons. I discuss the relevant symmetries of QCD and how they might affect the observed hadron properties. I then discuss at length the observable consequences of in-medium changes of hadronic properties in reactions with elementary probes, and in particular ...
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source