Results 71 to 80 of about 10,021,593 (283)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Polytope: an algorithm for efficient feature extraction on hypercubes

Journal of Big Data
Data extraction algorithms on data hypercubes, or datacubes, are traditionally only capable of cutting boxes of data along the datacube axes. For many use cases however, this returns much more data than users actually need, leading to an unnecessary ...
Mathilde Leuridan, James Hawkes, Simon Smart, Emanuele Danovaro, Martin Schultz, Tiago Quintino   +5 more
doaj   +1 more source

The medium in heavy-ion collisions

, 2006
The nuclear index of refraction, the density of partons, their free path length and energy loss in the matter created in heavy-ion collisions at RHIC are estimated within the suggestion that the emission of Cherenkov gluons is responsible for the ...
Dremin, Dremin, Dremin, Dremin, Feynman, Heinz, I.M. Dremin, Khoze, Koch, Landau, Majumder, Ruppert, Stöcker, Vitev, Wang, Wang, Wang   +16 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Global Probability‐Of‐Fire (PoF) Forecast

Geophysical Research Letters
Accurate wildfire forecasting can inform regional management and mitigation strategies in advance of fire occurrence. Existing systems typically use fire danger indices to predict landscape flammability, based on meteorological forecasts alone, often ...
J. R. McNorton, F. Di Giuseppe, E. Pinnington, M. Chantry, C. Barnard   +4 more
doaj   +1 more source

Astrophysical Fractals: Interstellar Medium and Galaxies

, 1999
The interstellar medium is structured as a hierachy of gas clouds, that looks self-similar over 6 orders of magnitude in scales and 9 in masses. This is one of the more extended fractal in the Universe.
Combes, F.
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Heat transfer in a complex medium

, 2016
The heat equation is considered in the complex medium consisting of many small bodies (particles) embedded in a given material. On the surfaces of the small bodies an impedance boundary condition is imposed.
A. G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, A.G. Ramm, B.M. Levitan, V. Jikov   +14 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source