Results 61 to 70 of about 729,280 (261)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

ENGLISH MEDIUM INSTRUCTION IN ASIAN UNIVERSITIES: SOME CONCERNS AND A SUGGESTED APPROACH TO DUAL-MEDIUM INSTRUCTION

Indonesian Journal of Applied Linguistics, 2014
: An increasing number of universities across the world are adopting English as the medium of instruction, particularly at the graduate level. This paper begins by briefly describing the historical development of such English medium instruction (EMI ...
Roger Barnard
doaj   +1 more source

Instruction via Chat: Does Co-Browse Help? [PDF]

, 2006
Purpose – The purpose of this research is to determine whether instruction would be welcomed by instant messaging (IM)/chat users, whether instruction is possible in this medium, whether it can be effectively provided, and if the use of co-browsing ...
Desai, Christina M., Graves, Stephanie J.   +1 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mother tongue instructions as a human right

Namibian Journal of Linguistics, Literature and Communication Studies
The paper aimed at studying the challenges as well as the potential benefits associated with using African languages as the main medium of instructions in Namibian schools.
Christian Harris
doaj   +1 more source

Social Media in the Dental School Environment, Part B: Curricular Considerations [PDF]

, 2015
The goal of this article is to describe the broad curricular constructs surrounding teaching and learning about social media in dental education. This analysis takes into account timing, development, and assessment of the knowledge, skills, attitudes ...
Chambers, David, Donate-Bartfield, Evelyn, Karimbux, Nadeem, McAndrew, Maureen, Spallek, Heiko, Turner, Sharon P., Zarkowski, Pamela   +6 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

“Your brother is compelled–not a hero!”

L’Année du Maghreb
Despite the “perpetual” implementation of the Arabisation policy in Algeria, French remains the de facto medium of instruction (MOI) in scientific courses in Algerian universities. The complex nature of MOI policy in Algeria calls for the need to explore
Imene Medfouni
doaj   +1 more source

Eksperimentasi Model Pembelajaran Kooperatif Tipe Numbered Heads Together (Nht) Dan Think Pair Share (Tps) Pada Materi Pokok Trigonometri Ditinjau Dari Kecerdasan Emosional Siswa Smk Di Kota Madiun Tahun Pelajaran 2013/2014 [PDF]

, 2014
The aims of the research were to find out: (1) which produces better mathematics learning achievement among cooperative learning model Numbered Heads Together (NHT), Think Pair Share (TPS), or direct instruction model; (2) which have better learning ...
Budiyono, B. (Budiyono), Sujadi, I. (Imam), Wahyuni, E. T. (Eva)   +2 more
core