Results 71 to 80 of about 205,356 (265)

Association of medullary sponge kidney and hyperparathyroidism with RET G691S/S904S polymorphism: a case report

Journal of Medical Case Reports, 2018
Background Medullary sponge kidney is a rare renal malformation, which usually manifests as nephrocalcinosis, renal tubular acidosis, and recurrent urinary tract infections.
Muhammad Usman Janjua, Xiao-dan Long, Zhao-hui Mo, Chang-sheng Dong, Ping Jin   +4 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction.

PLoS ONE, 2018
Following positive selection, thymocytes migrate into the medulla where they encounter diverse self-antigens that induce central tolerance. Thymocytes expressing T cell receptors (TCRs) with high affinity for self-antigens displayed by medullary antigen ...
Hiran M Thyagarajan, Jessica N Lancaster, Sergio A Lira, Lauren I R Ehrlich   +3 more
doaj   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma

Clinics, 2009
Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary ...
Sergio PA Toledo, Delmar M Lourenço Jr, Marcelo Augusto Santos, Marcos R Tavares, Rodrigo A Toledo, Joya Emilie de Menezes Correia-Deur   +5 more
doaj   +1 more source

Medullary Carcinoma [PDF]

Journal of the National Comprehensive Cancer Network, 2010
R Michael, Tuttle, Douglas W, Ball, David, Byrd, Gilbert H, Daniels, Raza A, Dilawari, Gerard M, Doherty, Quan-Yang, Duh, Hormoz, Ehya, William B, Farrar, Robert I, Haddad, Fouad, Kandeel, Richard T, Kloos, Peter, Kopp, Dominick M, Lamonica, Thom R, Loree, William M, Lydiatt, Judith, McCaffrey, John A, Olson, Lee, Parks, John A, Ridge, Jatin P, Shah, Steven I, Sherman, Cord, Sturgeon, Steven G, Waguespack, Thomas N, Wang, Lori J, Wirth   +25 more
openaire   +2 more sources

Models of the medullary microcirculation

Kidney International, 1987
The medullary microcirculation includes the descending vasa recta (DVR) and ascending vasa recta (AVR), vessels that run in parallel from the corticomedullary junction toward the papillary tip. At intervals, a DVR leaves the bundle of vessels to supply the adjacent capillary plexus.
McNeely, Elizabeth A., Pallone, Thomas L., Deen, William M., Robertson, Channing R.   +3 more
openaire   +2 more sources

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites

Angewandte Chemie, EarlyView.
We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan, Andrew J. Tague, Ashna A. Kumar, Marie Ranson, Christopher J. T. Hyland, Shane R. Ellis   +5 more
wiley   +2 more sources