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Intertumoral Heterogeneity within Medulloblastoma Subgroups [PDF]
Cancer Cell, 2017 While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary ...
Florence M G Cavalli +2 more
exaly +4 more sources
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases [PDF]
Cell, 2018 While the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to a dearth of metastatic tissue samples and model systems.
Noriyuki Kijima +2 more
exaly +3 more sources
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Clinical Oncology, 2013
Medulloblastomas are primary malignant embryonal tumours of the central nervous system. They are the most common childhood central nervous system tumour, but are rare in the adult population. They arise infratentorially in the cerebellum or fourth ventricle and hence the most common presenting symptoms are those associated with raised intracranial ...
F, Bartlett, R, Kortmann, F, Saran
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Medulloblastomas are primary malignant embryonal tumours of the central nervous system. They are the most common childhood central nervous system tumour, but are rare in the adult population. They arise infratentorially in the cerebellum or fourth ventricle and hence the most common presenting symptoms are those associated with raised intracranial ...
F, Bartlett, R, Kortmann, F, Saran
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Current Opinion in Neurology, 1999
The utilization of multi-modal therapy in the treatment of medulloblastoma has improved survival rates and overall outcome. Recent large clinical trials have supported the use of radiation and chemotherapy as adjuvant treatment. Treatment advances have been made despite a poor understanding of the biological underpinnings of medulloblastoma.
A T, Reddy, R J, Packer
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The utilization of multi-modal therapy in the treatment of medulloblastoma has improved survival rates and overall outcome. Recent large clinical trials have supported the use of radiation and chemotherapy as adjuvant treatment. Treatment advances have been made despite a poor understanding of the biological underpinnings of medulloblastoma.
A T, Reddy, R J, Packer
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min - Minimally Invasive Neurosurgery, 1993
81 patients with biopsy proven medulloblastoma with a mean age of 11.4 years were reviewed. Total removal of the tumour was accomplished in 18 cases (22.2%), subtotal removal in 55 cases (67.9%) and biopsy alone in 8 cases (9.9%). 34 patients (27.5%) had a recurrence of the tumour and 8 patients underwent a second posterior fossa exploration at the ...
H Z, Gökalp +5 more
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81 patients with biopsy proven medulloblastoma with a mean age of 11.4 years were reviewed. Total removal of the tumour was accomplished in 18 cases (22.2%), subtotal removal in 55 cases (67.9%) and biopsy alone in 8 cases (9.9%). 34 patients (27.5%) had a recurrence of the tumour and 8 patients underwent a second posterior fossa exploration at the ...
H Z, Gökalp +5 more
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Current Treatment Options in Neurology, 2003
Medulloblastomas, primitive neuroectodermal tumors of the cerebellum, comprise 20% of all pediatric brain tumors and are the most common solid neoplasm in children. Primitive neuroectodermal tumors are believed to arise from cerebellar granule cell precursors.
Catherine A., Mazzola, Ian F., Pollack
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Medulloblastomas, primitive neuroectodermal tumors of the cerebellum, comprise 20% of all pediatric brain tumors and are the most common solid neoplasm in children. Primitive neuroectodermal tumors are believed to arise from cerebellar granule cell precursors.
Catherine A., Mazzola, Ian F., Pollack
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Current Treatment Options in Neurology, 2012
The mainstay of medulloblastoma treatment is high-quality interdisciplinary collaboration in diagnosis, treatment, and aftercare by all involved disciplines. The first step in treatment of medulloblastoma is a maximal safe surgery, followed by thorough staging.
von Hoff, Katja, Rutkowski, Stefan
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The mainstay of medulloblastoma treatment is high-quality interdisciplinary collaboration in diagnosis, treatment, and aftercare by all involved disciplines. The first step in treatment of medulloblastoma is a maximal safe surgery, followed by thorough staging.
von Hoff, Katja, Rutkowski, Stefan
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Journal of Child Neurology, 2009
Medulloblastoma is the most common malignant brain tumor in children. Patients with medulloblastoma are stratified into ‘‘standard’’ and ‘‘high’’ risk categories based on age at diagnosis, degree of surgical resection, and disease spread. In children older than 3 years of age, the long-term survival can be achieved in approximately 85% of standard risk
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Medulloblastoma is the most common malignant brain tumor in children. Patients with medulloblastoma are stratified into ‘‘standard’’ and ‘‘high’’ risk categories based on age at diagnosis, degree of surgical resection, and disease spread. In children older than 3 years of age, the long-term survival can be achieved in approximately 85% of standard risk
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Acta Neurochirurgica, 1979
51 medulloblastomas under 12 years of age were treated from 1966 through 1977. 50 patients underwent craniotomy and 39 of them completed postoperative radiation therapy. Surgical mortality rate of primary posterior fossa craniotomy was 8%. One year survival rate was 71.4%, 3 years 45.6% and 5 years 34.5%.
A J, Raimondi, T, Tomita
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51 medulloblastomas under 12 years of age were treated from 1966 through 1977. 50 patients underwent craniotomy and 39 of them completed postoperative radiation therapy. Surgical mortality rate of primary posterior fossa craniotomy was 8%. One year survival rate was 71.4%, 3 years 45.6% and 5 years 34.5%.
A J, Raimondi, T, Tomita
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The ultrastructure of medulloblastomas
Acta Neuropathologica, 19709 medulloblastomas were investigated by electron microscopy. They all showed a rather unique histological and cytological structure. The cells were differently shaped, had in general many cytoplasmic processes and only few organells. Special differentiations which would have made tumour elements look like glial or neural cells were not observed when ...
F, Matakas +2 more
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