Results 1 to 10 of about 6,843,765 (355)

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial

EClinicalMedicine, 2021
Background: A vaccine against SARS-CoV-2 is of high urgency. Here the safety and immunogenicity induced by a DNA vaccine (INO-4800) targeting the full length spike antigen of SARS-CoV-2 are described.
Pablo Tebas, ShuPing Yang, Jean D. Boyer, Emma L. Reuschel, Ami Patel, Aaron Christensen-Quick, Viviane M. Andrade, Matthew P. Morrow, Kimberly Kraynyak, Joseph Agnes, Mansi Purwar, Albert Sylvester, Jan Pawlicki, Elisabeth Gillespie, Igor Maricic, Faraz I. Zaidi, Kevin Y. Kim, Yaya Dia, Drew Frase, Patrick Pezzoli, Katherine Schultheis, Trevor R.F. Smith, Stephanie J. Ramos, Trevor McMullan, Karen Buttigieg, Miles W. Carroll, John Ervin, Malissa C. Diehl, Elliott Blackwood, Mammen P. Mammen, Jessica Lee, Michael J. Dallas, Ami Shah Brown, Jacqueline E. Shea, J.Joseph Kim, David B. Weiner, Kate E. Broderick, Laurent M. Humeau   +37 more
doaj   +1 more source

Durability of response to VGX-3100 treatment of HPV16/18 positive cervical HSIL

Human Vaccines & Immunotherapeutics, 2021
VGX-3100 is an investigational DNA-based immunotherapy being developed as an alternative to surgery and ablation for cervical High-Grade Squamous Intraepithelial Lesion (HSIL) with the aim of preserving reproductive health while treating precancerous ...
Prakash K. Bhuyan, Michael Dallas, Kim Kraynyak, Timothy Herring, Matthew Morrow, Jean Boyer, Susan Duff, Joseph Kim, David B. Weiner   +8 more
doaj   +1 more source

Machine learning using longitudinal prescription and medical claims for the detection of non-alcoholic steatohepatitis (NASH)

BMJ Health & Care Informatics, 2022
Objectives To develop and evaluate machine learning models to detect patients with suspected undiagnosed non-alcoholic steatohepatitis (NASH) for diagnostic screening and clinical management.Methods In this retrospective observational non-interventional ...
Orla Doyle, Ozge Yasar, Patrick Long, Brett Harder, Hanna Marshall, Sanjay Bhasin, Suyin Lee, Mark Delegge, Stephanie Roy, Nadea Leavitt, John Rigg   +10 more
doaj   +1 more source

Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors

Journal for ImmunoTherapy of Cancer, 2021
Background Human telomerase reverse transcriptase (hTERT) is frequently classified as a ‘universal’ tumor associated antigen due to its expression in a vast number of cancers.
Laurent Humeau, David Weiner, Robert H Vonderheide, Matthew P Morrow, Trevor McMullan, Anthony F Shields, Ashish V Chintakuntlawar, Kimberly A Kraynyak, Autumn J McRee, Jennifer M Johnson, Weijing Sun, Jan Pawlicki, Albert J Sylvester, Robert Samuels, Joseph J Kim, Jean D Boyer, Jeffrey M Skolnik   +16 more
doaj   +1 more source

Targeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis

Frontiers in Pharmacology, 2022
Chitinase 1 (CHIT1) and chitinase 3-like-1 (CHI3L1), two representative members of 18-Glycosyl hydrolases family, are significantly implicated in the pathogenesis of various human diseases characterized by inflammation and remodeling.
Suh-Young Lee, Suh-Young Lee, Chang-Min Lee, Bing Ma, Suchitra Kamle, Jack A. Elias, Yang Zhou, Chun Geun Lee   +7 more
doaj   +1 more source

Multivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses

Viruses, 2021
The emergence of multiple concurrent infectious diseases localized in the world creates a complex burden on global public health systems. Outbreaks of Ebola, Lassa, and Marburg viruses in overlapping regions of central and West Africa and the co ...
Jingjing Jiang, Stephanie J. Ramos, Preeti Bangalore, Dustin Elwood, Kathleen A. Cashman, Sagar B. Kudchodkar, Katherine Schultheis, Holly Pugh, Jewell Walters, Jared Tur, Jian Yan, Ami Patel, Kar Muthumani, Connie S. Schmaljohn, David B. Weiner, Laurent M. Humeau, Kate E. Broderick   +16 more
doaj   +1 more source

Geographic variations in lipid-lowering therapy utilization, LDL-C levels, and proportion retrospectively meeting the ACC/AHA very high-risk criteria in a real-world population of patients with major atherosclerotic cardiovascular disease events in the United States

American Journal of Preventive Cardiology, 2021
Objective: We assessed national- and state-level geographic variations among patients with a history of ≥1 major atherosclerotic cardiovascular disease (ASCVD) event in: (1) the proportion of patients with retrospectively identified 2018 American College
Seth J. Baum, Pallavi B. Rane, Sasikiran Nunna, Mohdhar Habib, Kiran Philip, Kainan Sun, Xin Wang, Rolin L. Wade   +7 more
doaj   +1 more source

Oregon Wine Board Meeting Minutes September 11, 2012 [PDF]

, 2012
These meeting minutes list individuals in attendance and missing at the September 11, 2012 Oregon Wine Board (OWB) meeting, held via conference call. Dewey Weddington provided a marketing update focused on planning for Oregon Wine Month and the Oregon ...
Coutinho, F.H., Dutilh, B.E., Swings, J., Thompson, C., Thompson, F.L., Walter, J.M.   +5 more
core   +5 more sources

Immune Therapy Targeting E6/E7 Oncogenes of Human Paillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis

Vaccines, 2020
: Background: Recurrent respiratory papillomatosis (RRP) is a rare disorder characterized by the generation of papillomas of the aerodigestive tract, usually associated with human papilloma virus (HPV) subtypes 6, 11.
Charu Aggarwal, Roger B. Cohen, Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Jocelyn Cheung, Kelsie Dickerson, Veronique Schulten, Dawson Knoblock, Elisabeth Gillespie, Joshua M. Bauml, Jian Yan, Malissa Diehl, Jean Boyer, Michael Dallas, J. Joseph Kim, David B Weiner, Jeffrey M. Skolnik   +17 more
doaj   +1 more source

Meeting online or offline? Patterns and trends for co-resident couples in early 21st century Britain [PDF]

, 2020
Data from the 2010-12 National Survey of Sexual Attitudes and Lifestyles (NATSAL-3) are used to document trends and patterns in where co-resident couples in Britain first met, focusing specifically on the rapid rise of meeting online, which both echoes ...
Lampard, Richard
core   +1 more source