Results 1 to 10 of about 1,228,259 (265)
Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial
EClinicalMedicine, 2021 Background: A vaccine against SARS-CoV-2 is of high urgency. Here the safety and immunogenicity induced by a DNA vaccine (INO-4800) targeting the full length spike antigen of SARS-CoV-2 are described.Pablo Tebas, ShuPing Yang, Jean D. Boyer, Emma L. Reuschel, Ami Patel, Aaron Christensen-Quick, Viviane M. Andrade, Matthew P. Morrow, Kimberly Kraynyak, Joseph Agnes, Mansi Purwar, Albert Sylvester, Jan Pawlicki, Elisabeth Gillespie, Igor Maricic, Faraz I. Zaidi, Kevin Y. Kim, Yaya Dia, Drew Frase, Patrick Pezzoli, Katherine Schultheis, Trevor R.F. Smith, Stephanie J. Ramos, Trevor McMullan, Karen Buttigieg, Miles W. Carroll, John Ervin, Malissa C. Diehl, Elliott Blackwood, Mammen P. Mammen, Jessica Lee, Michael J. Dallas, Ami Shah Brown, Jacqueline E. Shea, J.Joseph Kim, David B. Weiner, Kate E. Broderick, Laurent M. Humeau +37 moredoaj +1 more sourceDurability of response to VGX-3100 treatment of HPV16/18 positive cervical HSIL
Human Vaccines & Immunotherapeutics, 2021 VGX-3100 is an investigational DNA-based immunotherapy being developed as an alternative to surgery and ablation for cervical High-Grade Squamous Intraepithelial Lesion (HSIL) with the aim of preserving reproductive health while treating precancerous ...Prakash K. Bhuyan, Michael Dallas, Kim Kraynyak, Timothy Herring, Matthew Morrow, Jean Boyer, Susan Duff, Joseph Kim, David B. Weiner +8 moredoaj +1 more sourceMachine learning using longitudinal prescription and medical claims for the detection of non-alcoholic steatohepatitis (NASH)
BMJ Health & Care Informatics, 2022 Objectives To develop and evaluate machine learning models to detect patients with suspected undiagnosed non-alcoholic steatohepatitis (NASH) for diagnostic screening and clinical management.Methods In this retrospective observational non-interventional ...Orla Doyle, Ozge Yasar, Patrick Long, Brett Harder, Hanna Marshall, Sanjay Bhasin, Suyin Lee, Mark Delegge, Stephanie Roy, Nadea Leavitt, John Rigg +10 moredoaj +1 more sourcePhase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors
Journal for ImmunoTherapy of Cancer, 2021 Background Human telomerase reverse transcriptase (hTERT) is frequently classified as a ‘universal’ tumor associated antigen due to its expression in a vast number of cancers.Laurent Humeau, David Weiner, Robert H Vonderheide, Matthew P Morrow, Trevor McMullan, Anthony F Shields, Ashish V Chintakuntlawar, Kimberly A Kraynyak, Autumn J McRee, Jennifer M Johnson, Weijing Sun, Jan Pawlicki, Albert J Sylvester, Robert Samuels, Joseph J Kim, Jean D Boyer, Jeffrey M Skolnik +16 moredoaj +1 more sourceTargeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis
Frontiers in Pharmacology, 2022 Chitinase 1 (CHIT1) and chitinase 3-like-1 (CHI3L1), two representative members of 18-Glycosyl hydrolases family, are significantly implicated in the pathogenesis of various human diseases characterized by inflammation and remodeling.Suh-Young Lee, Suh-Young Lee, Chang-Min Lee, Bing Ma, Suchitra Kamle, Jack A. Elias, Yang Zhou, Chun Geun Lee +7 moredoaj +1 more sourceMultivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses
Viruses, 2021 The emergence of multiple concurrent infectious diseases localized in the world creates a complex burden on global public health systems. Outbreaks of Ebola, Lassa, and Marburg viruses in overlapping regions of central and West Africa and the co ...Jingjing Jiang, Stephanie J. Ramos, Preeti Bangalore, Dustin Elwood, Kathleen A. Cashman, Sagar B. Kudchodkar, Katherine Schultheis, Holly Pugh, Jewell Walters, Jared Tur, Jian Yan, Ami Patel, Kar Muthumani, Connie S. Schmaljohn, David B. Weiner, Laurent M. Humeau, Kate E. Broderick +16 moredoaj +1 more sourceGeographic variations in lipid-lowering therapy utilization, LDL-C levels, and proportion retrospectively meeting the ACC/AHA very high-risk criteria in a real-world population of patients with major atherosclerotic cardiovascular disease events in the United States
American Journal of Preventive Cardiology, 2021 Objective: We assessed national- and state-level geographic variations among patients with a history of ≥1 major atherosclerotic cardiovascular disease (ASCVD) event in: (1) the proportion of patients with retrospectively identified 2018 American College Seth J. Baum, Pallavi B. Rane, Sasikiran Nunna, Mohdhar Habib, Kiran Philip, Kainan Sun, Xin Wang, Rolin L. Wade +7 moredoaj +1 more sourceImmune Therapy Targeting E6/E7 Oncogenes of Human Paillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis
Vaccines, 2020 : Background: Recurrent respiratory papillomatosis (RRP) is a rare disorder characterized by the generation of papillomas of the aerodigestive tract, usually associated with human papilloma virus (HPV) subtypes 6, 11.Charu Aggarwal, Roger B. Cohen, Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Jocelyn Cheung, Kelsie Dickerson, Veronique Schulten, Dawson Knoblock, Elisabeth Gillespie, Joshua M. Bauml, Jian Yan, Malissa Diehl, Jean Boyer, Michael Dallas, J. Joseph Kim, David B Weiner, Jeffrey M. Skolnik +17 moredoaj +1 more sourceAugmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100
Molecular Therapy: Oncolytics, 2016 We have previously demonstrated the immunogenicity of VGX-3100, a multicomponent DNA immunotherapy for the treatment of Human Papillomavirus (HPV)16/18-positive CIN2/3 in a phase 1 clinical trial.Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Xuefei Shen, Dinah Amante, Lindsay Sakata, Lamar Parker, Jian Yan, Jean Boyer, Christian Roh, Laurent Humeau, Amir S Khan, Kate Broderick, Kathleen Marcozzi-Pierce, Mary Giffear, Jessica Lee, Cornelia L Trimble, J Joseph Kim, Niranjan Y Sardesai, David B Weiner, Mark L Bagarazzi +20 moredoaj +1 more source
