Results 81 to 90 of about 22,109 (243)

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis. [PDF]

, 2013
ObjectiveEtrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are implicated in leucocyte migration and retention in ulcerative colitis (UC).
Baumgart, Daniel C, Bressler, Brian, Danilenko, Dimitri, Egen, Jackson, Fedorak, Richard N, Hommes, Daan W, Keir, Mary, Luca, Diana, Mansfield, John C, O'Byrne, Sharon, Rutgeerts, Paul J, Schreiber, Stefan, Sturm, Andreas, Tang, Meina, Visich, Jennifer, Wei, Xiaohui, Williams, Marna   +16 more
core  

Association of chagasic megacolon and cancer of the colon: case report and review of the literature

Revista da Sociedade Brasileira de Medicina Tropical, 2002
There are few descriptions of association between chagasic megacolon and colon cancer. We report a case of obstructive abdomen caused by adenocarcinoma of the left colon in chagasic megacolon.
Sheila Jorge Adad, Renata Margarida Etchebehere, José Ribamar de Araújo, Andrea Berdu Madureira, Vanessa Guimarães Freitas Lima, Alex Augusto da Silva, Crema Eduardo   +6 more
doaj  

A novel MBTPS2 missense variant identifying keratosis follicularis spinulosa decalvans in a case of neonatal erythroderma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Edwin Cuperus, Michel van Geel, Virginie JM Verhoeven, Suzanne M Koudijs, Gerharda H Boerman, Angela M Tjiam, N Margreth van der Lugt, Suzanne GMA Pasmans   +7 more
wiley   +1 more source

Andrias Davidianus Peptide Hydrogel Enables Sustained SR9011 Release to Promote Efferocytosis and Alleviate Colitis

Small, Volume 21, Issue 50, December 17, 2025.
NR1D1 suppresses epithelial CD47 transcription to promote efferocytosis by macrophages. In UC, NR1D1 expression is diminished, leading to CD47 upregulation, inhibition of apoptotic cell clearance, and exacerbation of intestinal inflammation. Restoring rhythmic NR1D1 activation using SR9011‐loaded bioadhesive hydrogel enhances efferocytosis, improves ...
Yidong Chen, Jiamin Li, Junrong Li, Xiaopeng Zhang, Fang Liu, Qi Yu, Rong Lin, Liangru Zhu   +7 more
wiley   +1 more source

Enfermedad de Hirschsprung en el niño

Cirugía del Uruguay, 2020
Presentado en sesión de 13 de noviembre de ...
César H Arruti, Ruben Añón
doaj   +2 more sources

HSV1/2 Genital Infection in Mice Cause Reversible Delayed Gastrointestinal Transit: A Model for Enteric Myopathy

Frontiers in Medicine, 2018
In an interesting investigation by Khoury-Hanold et al. (1), genital infection of mice with herpes simplex virus 1 (HSV1) were reported to cause multiple pelvic organ involvement and obstruction.
Arun Chaudhury, Vijaya Sena Reddy Dendi, Mousumi Chaudhury, Astha Jain, Madhukar Reddy Kasarla, Kiran Panuganti, Gaurav Jain, Abhijit Ramanujam, Bhavin Rena, Sudheer Reddy Koyagura, Sumit Fogla, Sunil Kumar, Nawal Singh Shekhawat, Srinivas Maddur, Srinivas Maddur   +14 more
doaj   +1 more source

Risk factors for recurrence in patients with Clostridium difficile infection due to 027 and non-027 ribotypes [PDF]

, 2018
Objectives: Our objective was to evaluate factors associated with recurrence in patients with 027+ and 027– Clostridium difficile infection (CDI). Methods: Patients with CDI observed between January and December 2014 in six hospitals were consecutively ...
Aceti, A., Andreoni, M., Antonelli, G., Carfagna, P., Cauda, R., Delle Rose, D., Falcone, M., Fantoni, M., Farcomeni, A., Fontana, C., Goldoni, P., Iraci, F., Mastroianni, C., Murri, R., Petrosillo, N., Raponi, G., Sanguinetti, M., Santino, I., Tiseo, G., Venditti, M.   +19 more
core   +1 more source

Awareness of Microbiological Safety in Playgrounds Amid Rising Antibiotic Resistance

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Playgrounds are identified as reservoirs for antibiotic‐resistant bacteria, posing a potential public health risk. Despite the existence of safety regulations for playground equipment, microbiological safety is treated superficially. Global strategies, including hygiene practices and antibacterial materials, are needed to reduce the spread of ...
Rafał Łopucki, Marcin Skowronek, Anna Bilokinna, Guillermo Martinez‐de‐Tejada, Ilona Sadok   +4 more
wiley   +1 more source

Profile of interstitial cells of Cajal in a murine model of chagasic megacolon [PDF]

Anais da Academia Brasileira de Ciências
Disorders of gastrointestinal motility are the major physiologic problem in chagasic megacolon. The contraction mechanism is complex and controlled by different cell types such as enteric neurons, smooth muscle, telocytes, and an important pacemaker of ...
MAYRA FERNANDA RICCI, ANA L. MAZZETI, JOANA L. BARBOSA, FABIANA S. MACHADO, MARIA TEREZINHA BAHIA, ROSA MARIA E. ARANTES, SAMANTHA R. SOUZA   +6 more
doaj   +1 more source

Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease [PDF]

, 2017
Hirschsprung disease, or congenital megacolon, is characterized by aganglionosis of the terminal bowel, which leads to intestinal obstruction and chronic constipation. Several genes involved in the disease have been identified.
Eichenberger, Christof, Paratore, Christian, Sommer, Lukas, Suter, Ueli   +3 more
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