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Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe
In a study of the pathogenesis and clinical features of megaloblastic anaemia in southern Africa, we evaluated 144 consecutive Zimbabwean patients with megaloblastic haemopoiesis.
Innocent Gangaidzo, J Lindenbaum
exaly +1 more source
Clinicopathological features of megaloblastic anaemia in Hong Kong: a study of 84 Chinese patients
Megaloblastic anaemia is uncommon in Hong Kong. Eighty-four consecutive Chinese patients with megaloblastic anaemia were studied. There were 48 males and 36 females, with a median age at presentation of 67 years.
Liang, RHS +4 more
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Megaloblastic anaemia in Uganda
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1969Abstract 45 patients with primary megaloblastic anaemia—forming 2% of anaemic in-patients in Kampala—are reviewed. The diversity of aetiological factors and importance of haemorrhage due to thrombocytopenia are stressed.
F, Lothe, K M, Patel, R A, Tozer
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Diagnosis of megaloblastic anaemias
Blood Reviews, 2006There are a large number of causes of megaloblastic anaemia. The most frequent are disorders resulting in vitamin B(12) or folate deficiency. The diagnostic process often consists first of establishing the presence of B(12) or folate deficiency and then of determining the cause of deficiency. The blood count, blood film, serum B(12) assay, and red cell
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Concealed megaloblastic anaemia
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1959Abstract During the study of some 1,300 patients in Malaya suffering from nutritional anaemia, 25 presented with signs of a pure iron-deficiency anaemia, including a normoblastic bone marrow picture. On treatment with parenteral iron little improvement of the anaemia took place and the bone marrow was later found to be grossly megaloblastic.
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Megaloblastic Anaemia in Pregnancy
Australian and New Zealand Journal of Obstetrics and Gynaecology, 1967summaryThe Serum folic acid and vitamin B12 levels have been investigated in a clinically normal series of 97 patients. There was tendency for subnormal values to be reached toward the end of pregnancy in serum folic acid levels but not in those of vitamin B12.an analysis of 9 patient with established megaloblastic anaemia seen in the period tendency ...
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Anticonvulsants and Megaloblastic Anaemia
Journal of Mental Science, 1959The development of megaloblastic anaemia as a complication of anticonvulsant therapy is now well recognized, and a total of thirty cases has been recorded.Badenoch (1) reported the first detailed studies of megaloblastic anaemia developing in epileptic patients treated with phenobarbitone and epanutin, whilst Fuld and Moorhouse (6) reported the ...
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Megaloblastic anaemia in Asians in Singapore
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1966Abstract 21 consecutive Asian patients in Singapore with megaloblastic anaemia were studied. In 4 the megaloblastic anaemia was due to vitamin B12 deficiency. 3 of these patients were considered to have pernicious anaemia; in the other, vitamin B12 deficiency had arisen as a result of gastrectomy. 2 patients had tropical sprue.
S C, Siang, N W, England, W, O'Brien
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Thymidylate concentration in megaloblastic anaemia
Nature, 1974MEGALOBLASTIC anaemia is thought to be caused by a disturbance of DNA synthesis in the bone marrow. The most common causes are deficiencies of folate or vitamin B12 which are thought to interfere directly or indirectly with supply of thymidine triphosphate (dTTP, thymidylate) one of the four immediate precursors of DNA1,2 (Fig. 1).
A V, Hoffbrand +4 more
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Tropical megaloblastic anaemia
The Lancet, 2019Himmatrao Saluba, Bawaskar +3 more
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