Results 1 to 10 of about 754,903 (204)
Meibocyte differentiation and renewal: Insights into novel mechanisms of meibomian gland dysfunction (MGD) [PDF]
Experimental Eye Research, 2017 This paper reviews our current understanding of age-related meibomian gland dysfunction (MGD) and the role of the nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARĪ³), in the regulation of meibomian gland function, meibocyte differentiation and lipid synthesis.
Geraint J Parfitt +2 more
exaly +9 more sources
Modeling meibum secretion: Alternatives for obstructive Meibomian Gland Dysfunction (MGD) [PDF]
Ocular SurfaceWhile changes in meibum quality are correlated with severity of meibomian gland dysfunction (MGD) and dry eye disease, little is known regarding the mechanics of meibum secretion. The purpose of this study was to develop a finite element model of meibum secretion and evaluate the effect of various factors that might impact meibum delivery to the ocular
James Jester +2 more
exaly +5 more sources
Latest developments on meibomian gland dysfunction: Diagnosis, treatment and management [PDF]
African Vision and Eye Health, 2022 Background:Ā Meibomian gland dysfunction (MGD) is one of the leading causes of evaporative dry eye disease and one of the most common ophthalmic conditions found in clinical practice.
Solani D. Mathebula
doaj +2 more sources
Candidate Molecular Compounds as Potential Indicators for Meibomian Gland Dysfunction
Frontiers in Medicine, 2022 Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease throughout the world. Studies have shown that several molecules in meibum, including but not limited to interleukins, amino acids, cadherins, eicosanoids, carbohydrates, and ...
Kofi Asiedu
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Current Issues in Molecular Biology, 2023 Meibomian gland dysfunction (MGD) is a functional and morphological disorder of the meibomian glands which results in qualitative or quantitative alteration in meibum secretion and is the major cause of evaporative dry eye (EDE).
Ya-Li Du +9 more
doaj +2 more sources
Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease [PDF]
Endocrine JournalThe meibomian glands play a central role in maintaining ocular surface homeostasis by producing meibum, which is the lipid layer of the tear film that suppresses tear evaporation.
Takahito Miyake, Masao Doi
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Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications [PDF]
International Journal of Ophthalmology, 2021 Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation.
Li-Xiang Wang, Ying-Ping Deng
doaj +1 more source
A review of rabbit models of meibomian gland dysfunction and scope for translational research
Indian Journal of Ophthalmology, 2023 Dry eye disease (DED) is an emerging global health concern with meibomian gland dysfunction (MGD) being the most common subtype of DED. Despite being quite prevalent, the pathophysiological mechanisms governing MGD are poorly understood.
Deeksha Prasad +10 more
doaj +1 more source
Frontiers in Medicine, 2022 Objective: To observe differences in meibomian gland morphology among patients with meibomian gland dysfunction (MGD) with liquid meibum, with solid meibum, and a non-MGD group by laser scanning in vivo confocal microscopy (IVCM), and then analyze the ...
Qian Zheng +9 more
doaj +1 more source
Digital Chinese Medicine, 2020 The meibomian gland is a unique sebaceous gland located in the eyelid. Its main function is to secrete lipids and form the lipid layer of the tear film to delay the evaporation of waterborne tears, increase the surface tension of the tear film, and to ...
Li Jie +4 more
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