Meibocyte differentiation and renewal: Insights into novel mechanisms of meibomian gland dysfunction (MGD) [PDF]
Experimental Eye Research, 2017 This paper reviews our current understanding of age-related meibomian gland dysfunction (MGD) and the role of the nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARγ), in the regulation of meibomian gland function, meibocyte differentiation and lipid synthesis.
Geraint Parfitt +2 more
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Therapeutic Effect of Intense Pulsed Light (IPL) Combined with Meibomian Gland Expression (MGX) on Meibomian Gland Dysfunction (MGD). [PDF]
J Ophthalmol, 2020 Purpose. Our study aimed to evaluate the efficiency of intense pulsed light (IPL) combined with meibomian gland expression (MGX) in treating meibomian gland dysfunction (MGD). Methods. This study was a prospective interventional study. A total of 53 patients were included in the study and received a series of three treatments at an interval of 3-4 ...
Wei S +5 more
europepmc +5 more sources
Modeling meibum secretion: Alternatives for obstructive Meibomian Gland Dysfunction (MGD). [PDF]
Ocul SurfWhile changes in meibum quality are correlated with severity of meibomian gland dysfunction (MGD) and dry eye disease, little is known regarding the mechanics of meibum secretion. The purpose of this study was to develop a finite element model of meibum secretion and evaluate the effect of various factors that might impact meibum delivery to the ocular
Luo S +5 more
europepmc +6 more sources
Clinical signs of meibomian gland dysfunction (MGD) are associated with changes in meibum sphingolipid composition. [PDF]
Ocul Surf, 2019 Sphingolipids (SPL) play roles in cell signaling, inflammation, and apoptosis. Changes in SPL composition have been reported in individuals with MGD, but associations between clinical signs of MGD and compositional changes in meibum SPLs have not been examined.Forty-three individuals underwent a tear film assessment.
Paranjpe V +6 more
europepmc +4 more sources
Meibomian gland dysfunction (MGD), as diagnosed by non-contact infrared Meibography, in dogs with ocular surface disorders (OSD): a retrospective study. [PDF]
BMC Vet Res, 2019 Abstract Background: Meibomian gland dysfunction (MGD) is one of the possible conditions underlying ocular surface disorders (OSD). Prevalence of MGD in dogs affected by OSD has not yet been reported. We aimed to evaluate the prevalence of MGD among OSD canine patients, which had been assessed by non-contact infrared meibography and ...
Viñas M +4 more
europepmc +5 more sources
The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on the Epidemiology of, and Associated Risk Factors for, MGD [PDF]
Investigative Opthalmology & Visual Science, 2011 Scientists have been interested in studying the secretions of the meibomian glands for many years, 1– 8 and diseases associated with the meibomian glands (e.g., cancers, posterior blepharitis) have been noted in the medical literature since at least the early part of the 20th Century. 9 –13 However, the term “meibomian gland dysfunction” (MGD) was only
Miki Uchino, L Tong, Jason Nichols
exaly +3 more sources
Efficacy and safety of perfluorohexyloctane (PFHO) in patients with dry eye disease (DED) due to meibomian gland dysfunction (MGD): Systematic review and meta-analysis. [PDF]
Medicine (Baltimore)Background: Dry eye disease (DED) associated with meibomian gland dysfunction lacks a conclusive treatment, placing existing solutions under the burden of side effects and limitations. This study seeks to assess the efficacy and safety of perfluorohexyloctane (PFHO) in treating DED associated with meibomian gland dysfunction.
Munsab R +8 more
europepmc +3 more sources
Contact Lens and Anterior EyeMeibomian gland dysfunction (MGD) is a common disease, yet there is no standard clinical definition. This study explored the frequency and characteristics of MGD in dry eye disease (DED) using different clinical definitions.A secondary analysis of data collected from the DREAM© study participants (n = 535) with moderate-to-severe DED was undertaken ...
Gui-Shuang Ying +2 more
exaly +3 more sources
Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease [PDF]
Endocrine JournalThe meibomian glands play a central role in maintaining ocular surface homeostasis by producing meibum, which is the lipid layer of the tear film that suppresses tear evaporation.
Takahito Miyake, Masao Doi
doaj +2 more sources
Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications [PDF]
International Journal of Ophthalmology, 2021 Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation.
Li-Xiang Wang, Ying-Ping Deng
doaj +1 more source