Results 51 to 60 of about 90,106 (297)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes

Nature Communications
In mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation and embryonic development. Prophase arrest
Shiya Cheng, Melina Schuh
doaj   +1 more source

Cdc14 phosphatase directs centrosome re-duplication at the meiosis I to meiosis II transition in budding yeast [version 1; referees: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2017
Background Gametes are generated through a specialized cell division called meiosis, in which ploidy is reduced by half because two consecutive rounds of chromosome segregation, meiosis I and meiosis II, occur without intervening DNA replication.
Colette Fox, Juan Zou, Juri Rappsilber, Adele L. Marston   +3 more
doaj   +1 more source

Homologous recombination, sister chromatid cohesion, and chromosome condensation in mammalian meiosis [PDF]

, 2002
In the life cycle of sexually reproducing eukaryotes, haploid and diploid generations of cells alternate. Two types of cell division occur in such a life cycle: mitosis and meiosis. They are compared in chapter 1 .
Eijpe, M.
core  

Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk [PDF]

, 2011
During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead
Sourav Sarkar, Millar, Jonathan B.A., Kerr, Gary W., Tibbles, Katherine L., Prakash Arumugam, Kerr, Gary, Gary W. Kerr, Sarkar, Sourav, Millar, Jonathan B. A., Katherine L. Tibbles, Jonathan B.A. Millar, Arumugam, Prakash, Mark Petronczki, Petronczki, Mark   +13 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes

Cell Reports, 2016
Summary: Mammalian oocytes are stored in the ovary, where they are arrested in prophase for prolonged periods. The mechanisms that abrogate the prophase arrest in mammalian oocytes and reinitiate meiosis are not well understood.
Thomas Tischer, Melina Schuh
doaj   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Meiosis in a living crane fly spermatocyte [Meiosis II] [PDF]

, 2016
Presents the events of meiosis II in two living spermatocytes obtained from the testis of a crane-fly larva are viewed in polarized light and recorded in this time-lapse sequence beginning at prophase II through telophase II to the near completion of ...
Oldenbourg, Rudolf, La Fountain Jr., James   +1 more
core   +2 more sources

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

Nature Communications
Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes.
Andreas Heim, Shiya Cheng, Jan Orth, Florian Stengel, Melina Schuh, Thomas U. Mayer   +5 more
doaj   +1 more source