Results 101 to 110 of about 18,943 (253)

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Reproductive analyses of intraspecific Paspalum notatum Flügge hybrids

Crop Breeding and Applied Biotechnology, 2020
Paspalum notatum is an important forage native to Southern Brazil and one of the most promising fodder species in terms of productivity, quality, resistance and growth speed. The objective of this study was to evaluate the reproductive mode and fertility
Karine Cristina Krycki, Marília Tedesco, Vitória Rodrigues, Roberto Luis Weiler, André Pich Brunes, Miguel Dall’Agnol, Carine Simioni   +6 more
doaj  

Meiotic Behavior of Wild, Synthetic and Cultivated Wheats

CYTOLOGIA, 2010
Wild relatives of bread wheat are potential sources of valuable genetic materials for wheat improvement. Genomic relationship and cross-ability between plant species can be deduced from chromosomal structure, size and behavior during meiotic division.
Arabbeigi, Mahbube, Arzani, Ahmad, Saeidi, Ghodratollah   +2 more
openaire   +2 more sources

Incorrect recombination partner associations contribute to meiotic instability of neo-allopolyploid Arabidopsis suecica

, 2023
Combining two or more related homoeologous genomes in a single nucleus, newly formed allopolyploids must rapidly adapt meiosis to restore balanced chromosome segregation, production of euploid gametes and fertility.
Petiot, V., Cheron, F., Lambing, Christophe, Lambing, C., White, Charles, White, C., Serra, H., Chéron, Floriane, Petiot, Valentine, Serra, Heïdi   +9 more
core   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Evolution, Expression and Meiotic Behavior of Genes Involved in Chromosome Segregation of Monotremes. [PDF]

Genes (Basel), 2021
Pajpach F, Shearwin-Whyatt L, Grützner F.   +2 more
europepmc   +1 more source

Meiotic Behavior of Achiasmate Sex Chromosomes in the African Pygmy Mouse Mus mattheyi Offers New Insights into the Evolution of Sex Chromosome Pairing and Segregation in Mammals. [PDF]

Genes (Basel), 2021
Gil-Fernández A, Ribagorda M, Martín-Ruiz M, López-Jiménez P, Laguna T, Gómez R, Parra MT, Viera A, Veyrunes F, Page J.   +9 more
europepmc   +1 more source