Results 181 to 190 of about 81,917 (261)

Malignant peripheral nerve sheath tumor development during MEK inhibitor treatment: A pre-clinical study and a clinical case series. [PDF]

Neurooncol Adv
Gross AM, Rhodes SD, Dufek A, Dombi E, Baldwin A, Shern JF, Sundby RT, Zhang X, Pekmezci M, Clapp DW, Pressey JG, Weiss BD, Bornhorst M, Kim A, Fisher MJ, Widemann BC.   +15 more
europepmc   +1 more source

TIM‐3 Functions as an Activator of NK Cells in GBM and Can Be Upregulated by Torin‐1: Implications for Exogenous NK Cell Transplantation

Immunology, EarlyView.
Unlike generalized mTOR inhibitors, Torin‐1 uniquely drives compensatory upregulation of TIM‐3 on human NK cells, shielding them from immunosuppression while concurrently inhibiting glioblastoma (GBM) growth. Selecting or preconditioning ex vivo NK cell products for high TIM‐3 expression can offer a combination strategy for adoptive cell therapy in GBM.
Yuning Liu, Tram Dao, Shambhavi Borde, Diana Dinh, Sofia Lombardi, Sandra Torregrosa‐Allen, Haley A. Harper, Veronika Slivova, Aaron Cohen‐Gadol, MacKenzie McIntosh, Bennet D. Elzey, Sandro Matosevic   +11 more
wiley   +1 more source

Sensitivity to immune checkpoint inhibitors in BRAF/MEK inhibitor refractory melanoma. [PDF]

J Immunother Cancer
Patel RP, Lim LRJ, Saleh R, Schenk D, Lee MK, Lelliott E, Rao AD, Arabi S, Smith L, Trigos AS, Haynes N, McArthur GA, Sheppard KE.   +12 more
europepmc   +1 more source

Five‐year survival impact of adjuvant anti‐PD‐1 therapy in a nationwide cohort of stage III melanoma

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This nationwide real‐world cohort study was unable to demonstrate a population‐level survival benefit of adjuvant anti‐PD‐1 in stage III melanoma. Matched analyses suggested higher OS in treated patients. However, limited statistical power and potential residual confounding preclude firm conclusions.
Marie B. Weitemeyer, Neel M. Helvind, Shawez Khan, Pernille Bidstrup, Karina D. Steffensen, Adam Andrzej Luczak, Lars Bastholt, Henrik Schmidt, Inge Marie Svane, Marco Donia, Lisbet R. Hölmich, Eva Ellebaek   +11 more
wiley   +1 more source

Monocytic meningitis complicating histiocytosis and response to MEK-inhibitor: a case series. [PDF]

Ann Hematol
Abrassart T, Idbaih A, Roos-Weil D, Galanaud D, Cohen-Aubart F, Emile JF, Boncoeur P, Amoura Z, Seilhean D, Haroche J, Papo M.   +10 more
europepmc   +1 more source

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance

Journal of Fish Biology, EarlyView.
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams, Les N. Harris, Jean‐Sébastien Moore, Ella K. Middleton, Shira A. Berkelhammer, Ben Speers‐Roesch, Matthew J. H. Gilbert   +6 more
wiley   +1 more source

Editorial expression of concern: ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells. [PDF]

J Exp Clin Cancer Res
Zhou S, Xia H, Xu H, Tang Q, Nie Y, Gong QY, Bi F.   +6 more
europepmc   +1 more source

Metaplasia and the Origins of Gastric Cancer—Implications for Screening and Surveillance

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Gastric intestinal metaplasia (IM) is a key step in the development of intestinal‐type gastric cancer (GC) and a checkpoint for preventive strategies. The risk of progression to GC is highest for incomplete IM and extensive severe IM as classified by scoring systems such as operative link on gastric intestinal metaplasia (OLGIM) assessment ...
Khay Guan Yeoh
wiley   +1 more source

Co-operative epigenetic remodelling by Setd2 deficiency and Kras mutation drives juvenile myelomonocytic leukaemia development and MEK inhibitor sensitivity. [PDF]

Br J Haematol
Munyurangabo G, Zhang L, Zhou Y, Zhang P, Yu X, Qu D, Yang D, Ren X, Liu H, Wu Y, Kong G, Yang Y.   +11 more
europepmc   +1 more source

Encorafenib‐associated acantholytic dermatosis in collision with eccrine squamous syringometaplasia

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Francisco Meraz‐Torres, Gabi Handgretinger, Andreas Meiwes, Derya Durak, Joana Schroth, Stephan Forchhammer   +5 more
wiley   +1 more source