Results 191 to 200 of about 81,917 (261)

Disruption of OsMAPKKK24 activation by the Xanthomonas oryzae effector XopY leads to compromised disease resistance in rice

Journal of Integrative Plant Biology, EarlyView.
The kinase OsRLCK55 phosphorylates OsMAPKKK24 to positively regulate rice resistance against Xanthomonas oryzae. To compromise this defense, the effector XopY targets OsMAPKKK24 and suppresses its autophosphorylation and the transphosphorylation mediated by OsRLCK55, ultimately leading to reduced disease resistance.
Lilan Chen, Yongming Chen, Wencai Xu, Xiaofang Wu, Shanshan Deng, Zhanchun Wang, Dingzhong Tang, Wei Wang   +7 more
wiley   +1 more source

Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer. [PDF]

Ther Adv Med Oncol
Ghosh S, Fan F, Powell R, Park YS, Stephan C, Kopetz ES, Ellis LM, Bhattacharya R.   +7 more
europepmc   +1 more source

Complete Regression of bilateral Choroidal Metastases secondary to a Cutaneous Melanoma under Immunotherapy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Yenny Angela, Alena Riesmeier, Ralf Gutzmer, Miltiadis Fiorentzis, Nikolaos E. Bechrakis, Carsten Framme, Ekaterina Sokolenko   +6 more
wiley   +1 more source

The Evolving Landscape of CHD Genetics: A Contemporary Guide to Genetic Testing and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most common birth defect, affecting an estimated 9.4/1000 infants globally. The genetics of CHD is complex, with most cases thought to have multifactorial aetiology, implicating both genetic and environmental factors.
Bridget R. O'Malley, Gary F. Sholler, Janine Smith, Gillian M. Blue   +3 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells. [PDF]

Cell Rep Med
Medina EF, Farmaki E, Griffiths JI, Bild AH, Nath A.   +4 more
europepmc   +1 more source

Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis. [PDF]

Front Mol Biosci
Bai J, Wan Z, Zhou W, Wang L, Lou W, Zhang Y, Jin H.   +6 more
europepmc   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Prospects of BRAF/MEK Inhibitor Therapy in Papillary Craniopharyngiomas with the BRAF V600E Mutation: A Scoping Review. [PDF]

Neurol Med Chir (Tokyo)
Fujio S, Ilmansyah R, Makino R, Juratli TA, Sugata J, Bakhtiar Y, Hanaya R.   +6 more
europepmc   +1 more source

Impact of Letermovir on Voriconazole Concentrations in Lung Transplant Patients

Transplant Infectious Disease, EarlyView.
Concomitant letermovir was associated with lower voriconazole exposure and reduced attainment of commonly used efficacy thresholds in lung transplant recipients. Routine therapeutic drug monitoring after letermovir initiation is recommended, and empiric voriconazole dose escalation may be needed to avoid subtherapeutic exposure. ABSTRACT Background The
Leah Georgiades, Sunish Shah, Erin K. McCreary, Fernanda Silveira, Raman Venkataramanan, Vignesh Vasudevan, Ryan M. Rivosecchi   +6 more
wiley   +1 more source