Results 221 to 230 of about 130,782 (308)

Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954

Hippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT An important mechanism controlling protein synthesis is through phosphorylation of the eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K. Hyperphosphorylation of eEF2 is linked to many neuronal diseases characterized by cognitive impairments.
Qian Yang, Tian Li, Hannah M. Jester, Qiang Su, Xueyan Zhou, Alexey G. Ryazanov, Tao Ma   +6 more
wiley   +1 more source

The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell carcinoma. [PDF]

Sci Rep
Katt WP, Balkman CE, Butler SD, Byron M, Carney PC, Todd-Donato AB, Drozd ME, Duhamel GE, Evans JM, Fiani N, Ford JC, Grenier JK, Hayward JJ, Heikinheimo K, Hume KR, Moore ES, Puri R, Sylvester SR, Warshaw SL, Webb SM, White AC, Wright AL, Cerione RA, Peralta S.   +23 more
europepmc   +1 more source

Sex‐Dependent Effects of Angiotensin II and Calcineurin in the Vasculature of Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim Cardiovascular diseases display strong sex differences. Angiotensin II (AngII) is implicated in this process. The ubiquitously expressed enzymatic beta subunit of calcineurin (PPP3CB), a serine/threonine phosphatase, can mediate pathological effects of AngII in the heart.
Alexander Nolze, Sindy Rabe, Stefanie Ruhs, Nicole Strätz, Katja Quarch, Conny Köhler, Claudia Grossmann   +6 more
wiley   +1 more source

Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study. [PDF]

Cancer Immunol Immunother
Beckmann M, Schlüter J, Erdmann M, Kramer R, Cunningham S, Hackstein H, Zimmermann R, Heinzerling L.   +7 more
europepmc   +1 more source

Identification of novel FGFR2::TXLNB Fusion in a polymorphous low‐grade neuroepithelial tumor of the young

Brain Pathology, Volume 36, Issue 3, May 2026.
We report a novel FGFR2::TXLNB fusion in a child with hippocampal PLNTY. This fusion likely drives tumorigenesis via homodimerization and activation of MAPK/PI3K pathways, expanding PLNTY's molecular spectrum and suggesting a potential therapeutic target.
Sha‐Sha Hu, Tian‐Yuan Tan, Wei Yan, Bo Wang   +3 more
wiley   +1 more source

Vitamin C and MEK Inhibitor PD0325901 Synergistically Promote Oligodendrocytes Generation by Promoting DNA Demethylation. [PDF]

Molecules
Ren X, Yang Y, Wang M, Yuan Q, Suo N, Xie X.   +5 more
europepmc   +1 more source

MEK/Aurora Kinase Inhibitor BI 847325 [PDF]

, 2020
openaire   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Successful Treatment of MEK Inhibitor-Induced Paronychia in Neurofibromatosis with Photodynamic Therapy: A Case Report and Review of the Therapeutic Options. [PDF]

J Clin Med
Ambrogio F, Perillo T, Bonamonte D, De Marco A, Tirone B, Laface C, Cazzato G, Foti C, Mortato E.   +8 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source