Results 91 to 100 of about 608,376 (286)
Advanced Science, EarlyView.We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza +19 more
wiley +1 more source
Steamship Portland: X-Storms [PDF]
In this lesson students will discover what causes extreme storms such as the Portland Gale of 1898 and the Halloween Nor'easter of 1991. They will identify and explain three factors that contributed to extreme storm conditions in the northwest Atlantic ...
Mel Goodwin
core
Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
BMC Primary CareBackground Community health workers (CHWs) remain an underutilized resource in social risk diagnostics in the primary care setting. This process evaluation study seeks to assess the role of CHWs in social risk screening, referral, and follow-up through ...
Emily K. Larson +8 more
doaj +1 more source
Estimation under Multicollinearity: Application of Restricted Liu and Maximum Entropy Estimators to the Portland Cement Dataset [PDF]
A high degree of multicollinearity among the explanatory variables severely impairs estimation of regression coefficients by the Ordinary Least Squares. Several methods have been suggested to ameliorate the deleterious effects of multicollinearity.
Mishra, SK
core +1 more source
Advanced Science, EarlyView.Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke +14 more
wiley +1 more source
Volcanism on the Pacific Ring of Fire: It's Going to Blow Up! (title provided or enhanced by cataloger) [PDF]
In this activity students familiarize themselves with some basic concepts of volcanology and investigate a portion of the Ring of Fire. They then research the answers to questions on the provided worksheet.
Mel Goodwin
core
Advanced Science, EarlyView.A lithium‐bearing slag is investigated with the goal of holistic valorization. The present β‐eucryptite (LiAlSiO4) exhibits a high lithium content and low levels of impurities. The spinel contains most of the chromium and vanadium, representing additional valorization opportunities.
Peter Cornelius Gantz +9 more
wiley +1 more source
Balanced costs: Inland copper smelting location and fuel in South Australia 1848-76: Were they so naive? [PDF]
Because it takes more than one ton of coal to smelt a similar quantity of minerals, and because coal is weight for weight less valuable than the mineral, it makes good logistical and economic sense to transport the mineral to the coal rather than vice ...
Mel Davies
core +1 more source