Results 191 to 200 of about 71,718 (296)

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi   +6 more
wiley   +1 more source

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen   +8 more
wiley   +1 more source

Grand Challenges in Virtual Environments

open access: yesFrontiers in Robotics and AI, 2014
Mel eSlater, Mel eSlater
doaj   +1 more source

Liposome-Encapsulated Melatonin Mitigates Amoxicillin-Induced Neurotoxicity in a Zebrafish. [PDF]

open access: yesJ Cell Mol Med
Balakrishnan R   +6 more
europepmc   +1 more source

Clinical Study to Evaluate Drug Interactions of Cannabidiol with Citalopram and Morphine in Healthy Adults

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is one of the most abundant bioactive cannabinoids. Research has demonstrated CBD’s ability to inhibit metabolic enzymes like cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), potentially leading to drug interactions. However, clinical knowledge gaps remain, particularly with regard to drugs that are more commonly taken by ...
Pablo Salcedo   +11 more
wiley   +1 more source

Chemical priming of strawberry plants under deficit irrigation enhances yield efficiency and physiological resilience. [PDF]

open access: yesSci Rep
Georgiadou EC   +7 more
europepmc   +1 more source

Predictors of Treatment Outcome in an Early Intervention Eating Disorder Sample

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To examine baseline predictors of treatment completion and clinical outcomes in 16 to 25‐year‐olds referred for early intervention for a recent‐onset eating disorder (ED). Method Participants (n = 228; 93% female, 63% White British) were drawn from the FREED‐Up study, which evaluated First episode Rapid Early intervention for EDs ...
Karina L. Allen   +13 more
wiley   +1 more source

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