Results 181 to 190 of about 27,981 (253)

Evaluation of the Safety and Therapeutic Range of Nanosecond Laser Treatment in Rabbits

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Subthreshold, nanosecond laser therapy has potential as a treatment for age‐related macular degeneration; however, the therapeutic range and safety profile have not been fully documented. In this study, rabbits were used for a preclinical assessment of nanosecond laser treatment.
Glyn Chidlow, John P. M. Wood, Weng Onn Chan, Robert J. Casson   +3 more
wiley   +1 more source

Diagnostic Utility of PRAME Immunohistochemistry for Distinguishing Acral Melanoma From Acral Melanocytic Nevi

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Introduction Preferentially expressed antigen in melanoma (PRAME) immunohistochemistry helps distinguish non‐acral melanocytic lesions, but few studies have addressed its value in acral lesions. We aimed to identify an optimal PRAME cut‐off score to differentiate acral melanoma (AM) from acral melanocytic nevi (AMN).
Kritsada Phatcharamaneepakorn, Panitta Sitthinamsuwan, Penvadee Pattanaprichakul, Manasmon Chairatchaneeboon, Nutcha Yodrabum   +4 more
wiley   +1 more source

Eruptive Acral Melanocytic Lesions Associated With Capecitabine

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Eruptive nevi and lentigines have been reported to occur in the setting of immunosuppression, which may be medication‐induced. The associated histopathologic findings have not been well described in the literature. Herein, we report the case of a woman in her 60s who had been receiving chemotherapy treatment with capecitabine, a prodrug of 5 ...
Madison Smith, Annie Jin, Jonathan A. Miles, Rosalie Elenitsas, Danielle M. DeHoratius, Emily Y. Chu   +5 more
wiley   +1 more source

Repositioning Non‐Ablative Fractional Lasers ‐ Molecular and Histological Insights from a scoping review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Near‐infrared non‐ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence‐dependent continuum of tissue modulation, based on evidence from 27 studies of lasers ...
Guy Erlich, Uwe Paasch, Kevin Jacobsen, Merete Haedersdal, Uffe Høgh Olesen   +4 more
wiley   +1 more source

International consensus recommendations for identifying malnutrition in children with neurological impairment

Developmental Medicine &Child Neurology, EarlyView.
Abstract Children with neurological impairment (CNI) are at increased risk of malnutrition because of functional, medical, and socioeconomic challenges. However, difficulties in obtaining reliable anthropometric measurements and differences in body composition limit the usefulness of conventional nutritional indicators.
Sarah Vermilyea, Jodi Wolff, Gina Rempel, Jessie M. Hulst, Koen Huysentruyt, Mandy Neudecker, Denise Kennedy, Valérie Marchand, Erika Ochoa‐Ortiz, Richard D. Stevenson, Promoting International Collaboration for Nutrition in Neurological Impairment in Children (PICNNIC) Working Group, Lucinda Lourens, Mark Conaway, Tejas S. Desai, Mercedes Ruiz Brunner, Nathalia Sanchez Vargas, Valeria Martinez Tenorio, Kristie L. Bell, Claudio Romano, Richard Grossberg   +19 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics and Exploratory Pharmacodynamics of Melanin‐Concentrating Hormone Receptor‐1 Antagonist RGH‐706 in Healthy and Overweight or Obese Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim This Phase 1 program evaluated the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of the novel melanin‐concentrating hormone receptor‐1 antagonist RGH‐706. Methods Study A was a first‐in‐man, randomized trial comprising a double‐blind, placebo‐controlled single‐ascending‐dose part (0.1–162.5 mg) and a two‐way ...
Thomas Brevig, Borbála Szepes, Zsófia Borbála Dombi, Gabriella Magyar, Zoltán Juhász, Margit Kapás, Éva Cseh, Zsuzsa Hegedűs, Tibor Farkas, Zsuzsanna Kiss, Balázs Szatmári   +10 more
wiley   +1 more source

The Importance of the Larval Parasitoid Actia interrupta (Diptera: Tachinidae) in Low Density Eastern Spruce Budworm Populations

Entomologia Experimentalis et Applicata, EarlyView.
Actia interrupta is an important larval tachinid parasitoid during low‐density populations of the eastern spruce budworm. In the late 1980s during the outbreak collapse, Meteorus trachynotus was initially the most important species, but was replaced by A. interrupta. Host patch size and density had no impact on the parasitism rates by A.
Véronique Martel, Jacques Régnière, Jean‐Claude Thireau   +2 more
wiley   +1 more source

Detection of NTRK1/2/3 rearrangements in pigmented spindle cell naevus of Reed: a comparative study of optimized pan‐TRK immunohistochemistry, FISH and RNA‐NGS

Histopathology, EarlyView.
Pigmented spindle cell nevus of Reed (PSCN) is a subtype of Spitz nevus mainly characterized by MYO5A::NTRK3 fusion. Our optimized pan‐TRK protocol stained 16/79 (20.3%) PSCNs (diffuse, granular, cytoplasmic staining of moderate intensity) and revealed high values of specificity (94.4%–96.2%) and positive predictive value (92.3%) for the detection of ...
Costantino Ricci, Barbara Corti, Sara Coluccelli, Giulia Calafato, Debora Anconelli, Francesco Vasuri, Martina Lambertini, Federico Venturi, Biagio Scotti, Alessia Grillini, Eugenia Franchini, Thais Maloberti, Antonio De Leo, Giovanni Tallini, Elisa Gruppioni, Annalisa Altimari, Michelangelo Fiorentino, Gerardo Cazzato, Emi Dika, Dario de Biase   +19 more
wiley   +1 more source

Convergent mutations underpin the repeated evolution of brown plumage in seabirds

Ibis, EarlyView.
Recent genetic data have provided crucial insights into the evolution of animal colour phenotypes, with the melanocortin‐1 receptor (MC1R) frequently implicated in dramatic colour shifts. However, the extent to which similar phenotypes are underpinned by convergent mutations at this locus remains unclear.
Shanshan Shen, Graham A. McCulloch, Tania M. King, Nicolas J. Rawlence, Martyn Kennedy, Jonathan M. Waters   +5 more
wiley   +1 more source

Impact of ultraviolet radiation‐induced damage to hair fiber integrity: A multi‐technique physicochemical characterization of surface and cortex properties

International Journal of Cosmetic Science, EarlyView.
UV exposure induces cuticular and cortical damage in natural hair, with oxidative effects and protein degradation comparable to bleaching. However, double bleaching leads to significantly greater structural degradation, emphasizing distinct mechanisms and severity of chemical versus UV‐induced damage. Abstract The combination of chemist techniques is a
Nathana Cindy Barros Silva Ramos, Alzira Xavier Pinto Dini, Viviane Cristina Albarici, Mayara Miranda Ferreira, Caroline Vieira Hercolino, Adriano da Silva Pinheiro, André Rolim Baby, Maria Valéria Robles Velasco   +7 more
wiley   +1 more source