Fungal Melanin and the Mammalian Immune System [PDF]
Journal of Fungi, 2021 Melanins are ubiquitous complex polymers that are commonly known in humans to cause pigmentation of our skin. Melanins are also present in bacteria, fungi, and helminths.
Sichen Liu +3 more
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Fungal melanin: what do we know about structure? [PDF]
Frontiers in Microbiology, 2015 The production of melanin significantly enhances the virulence of many important human pathogenic fungi. Despite fungal melanin’s importance in human disease, as well as melanin’s contribution to the ability of fungi to survive in diverse hostile ...
Joshua D Nosanchuk +2 more
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Fungal Melanin Biosynthesis Pathway as Source for Fungal Toxins [PDF]
mBio, 2022 Contamination of food and feed with toxin-producing fungi is a major threat in agriculture and for human health. The filamentous fungus Alternaria alternata is one of the most widespread postharvest contaminants and a weak plant pathogen.
Jia Gao +5 more
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The Enigmatic World of Fungal Melanin: A Comprehensive Review [PDF]
Journal of Fungi, 2023 Synthetic dyes are generally not safe for human health or the environment, leading to the continuous search and growing demand for natural pigments that are considered safer, biodegrade more easily, and are environmentally beneficial.
Malika Suthar +2 more
doaj +4 more sources
Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing [PDF]
Nature CommunicationsRespiratory infections caused by the human fungal pathogen Aspergillus fumigatus are a major cause of mortality for immunocompromised patients. Exposure to these pathogens occurs through inhalation, although the role of the respiratory epithelium in ...
Jennifer L. Reedy +16 more
doaj +3 more sources
Differential Antifungal Activity of Human and Cryptococcal Melanins with Structural Discrepancies [PDF]
Frontiers in Microbiology, 2017 Melanin is a pigment found in all biological kingdoms, and plays a key role in protection against ultraviolet radiation, oxidizing agents, and ionizing radiation damage. Melanin exerts an antimicrobial activity against bacteria, fungi, and parasites.
Néstor Correa +12 more
doaj +3 more sources
Fungal Melanin in Plant Pathogens: Complex Biosynthesis Pathways and Diverse Biological Functions [PDF]
PlantsFungal melanin plays a vital role in the survival, reproduction, infection, and environmental adaptation of plant pathogenic fungi. To develop innovative strategies for managing plant fungal diseases, comprehensive investigations into melanin are ...
Hui Jia +10 more
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Immunomodulatory functions of fungal melanins in respiratory infections [PDF]
mBioThe rate of invasive fungal infections has risen drastically over the last decade and continues to carry devastatingly high mortality rates. Currently, there are no licensed vaccines and limited antifungal agents in clinical trials for fungal-mediated ...
Kyle J. Basham +3 more
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Genetic, structural, and functional characterization of allomelanin from black yeast Exophiala viscosa, a chassis for fungal melanin production [PDF]
Applied Microbiology and BiotechnologyMelanized fungi are known for their remarkable resilience to environmental stress, largely attributed to the protective properties of melanin. In this study, we establish the black yeast Exophiala viscosa as a non-pathogenic, genetically tractable model ...
Tiffany M. Hennessa +8 more
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Subcellular Compartmentalization and Trafficking of the Biosynthetic Machinery for Fungal Melanin [PDF]
Cell Reports, 2016 Protection by melanin depends on its subcellular location. Although most filamentous fungi synthesize melanin via a polyketide synthase pathway, where and how melanin biosynthesis occurs and how it is deposited as extracellular granules remain elusive ...
Srijana Upadhyay +5 more
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