Results 251 to 260 of about 57,304 (322)

Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti‐PD1 resistance in skin cutaneous melanoma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors, such as anti­PD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács, Tamás Kovács, András Lánczky, Ágnes Paál, Zsombor I. Hegedűs, Nabil V. Sayour, Lilla Szabó, Andrea Kovács, Giampaolo Bianchini, Péter Ferdinandy, Alberto Ocana, Zoltán V. Varga, János Tibor Fekete, Balázs Győrffy   +13 more
wiley   +1 more source

An Electron Microscopic Study of Melanin in the Hair and Hair Follicles

, 1972
Richard S. Snell
openalex   +1 more source

Inhibition effects of Eucalyptus globules Labill. essential oil against tyrosinase. [PDF]

Sci Rep
Zhu H, Zhong X.
europepmc   +1 more source

Look past the cooperative eye hypothesis: reconsidering the evolution of human eye appearance

Biological Reviews, EarlyView.
ABSTRACT The external appearance of the human eye has been prominently linked to the evolution of complex sociocognitive functions in our species. The cooperative eye hypothesis (CEH) proposes that human eyeballs, with their weakly expressed conjunctival and scleral pigmentation, are uniquely conspicuous and evolved under selective pressures to behave ...
Juan Olvido Perea‐García, Aurora Teuben, Kai R. Caspar   +2 more
wiley   +1 more source

Characterization of melanin from Exophiala mesophila with the prospect of potential biotechnological applications. [PDF]

Front Fungal Biol
Medina-Armijo C, Yousef I, Berná A, Puerta A, Esteve-Núñez A, Viñas M, Prenafeta-Boldú FX.   +6 more
europepmc   +1 more source

Seasonal Variation in HLA‐B27 Associated Uveitis

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To examine if there was a monthly variation in HLA‐B27‐associated uveitis. Methods Retrospective review of all individuals presenting to a single centre with HLA‐B27‐associated uveitis from 2009 to 2020. Results 577 participants with HLA‐B27‐associated uveitis were included. The median age at presentation was 40.4 years (IQR 31.1–51.
Priya D. Samalia, James Brodie, Joanne L. Sims, Rachael L. Niederer   +3 more
wiley   +1 more source

Giant melanin granules in vitiliginous achromia with malignant melanoma

, 1978
Ortonne Jp, H Perrot
openalex   +2 more sources

1,8-Dihydroxynaphthalene (DHN) melanin provides unequal protection to black fungi Knufia petricola and Cryomyces antarcticus from UV-B radiation. [PDF]

Environ Microbiol Rep
Catanzaro I, Gorbushina AA, Onofri S, Schumacher J.   +3 more
europepmc   +1 more source

The Diverse Genetic Landscape of Hearing Impairment in South African Families

Clinical Genetics, EarlyView.
South African Families with Nonsyndromic (N = 24) and Syndromic Hearing Impairment (N = 21) with ≥ 2 affected members were analyzed. The underlying etiology was uncovered using exome and Sanger sequencing for 31 of these families. ABSTRACT To elucidate the genetic etiology of hearing impairment (HI) in South Africa, 45 nonsyndromic HI (NSHI) and ...
Thashi Bharadwaj, Anushree Acharya, Noluthando Rearabetswe Manyisa, Elvis Twumasi Aboagye, Ramses Peigou Wonkam, Lettilia Xhakaza, Kalinka Popel, Carmen de Kock, Isabelle Schrauwen, Ambroise Wonkam, Suzanne M. Leal   +10 more
wiley   +1 more source

Subcellular Demonstration of Peroxidatic Oxidation of Tyrosine to Melanin Using Dihydroxyfumarate as Cofactor in Mouse Melanoma Cells

, 1973
Milton R. Okun, Barbara Donnellan, Ravindra P. Patel, Leon M. Edelstein   +3 more
openalex   +1 more source