Results 151 to 160 of about 552,068 (289)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Exploring the Impact of Foods and Dietary Patterns on Melanoma Risk. [PDF]

Cureus
Kalavsky M, Abdul Gafoor SM.
europepmc   +1 more source

Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated [PDF]

, 2020
Muna Al Hashmi, Seetharama S Konduru, Lee Silcock, Lotfi Chouchane, Valentina Di Mattei, Nicola James, Rebecca Mathew, Davide Bedognetti, Valeria De Giorgi, Daniela Murtas, Wei Liu, Aouatef Ismail Chouchane, Ramzi Temanni, Barbara Seliger, Ena Wang, Francesco M. Marincola, Sara Tomei   +16 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

ETV4-Mediated PD-L1 Upregulation Promotes Immune Evasion and Predicts Poor Immunotherapy Response in Melanoma. [PDF]

Oncol Res
Zhu T, Wei T, Yang M, Xu J, Jiang H, He W, Zheng J, Dai H.   +7 more
europepmc   +1 more source

Development and Validation of an Extracellular Matrix Gene Expression Signature for Prognostic Prediction in Patients with Uveal Melanoma [PDF]

Alejandro Mejía‐García, Carlos A. Orozco, Jeremy Herzog, Oscar Alarcón-Betancourth, Alexandra Meneses-Torres, Claudia Espinosa, Johanna González, Yina Zambrano, Alba Lucía Cómbita, Diego A. Bonilla, Seth Frietze   +10 more
openalex   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Revisiting the alpha-synuclein paradox in melanoma-Parkinson's disease connection: more than a tale of two cell fates. [PDF]

Cell Mol Life Sci
Aiello J, Zamarato R, Moscheni C, Perrotta C, Clerici M, Trabattoni D, Biasin M, Limanaqi F.   +7 more
europepmc   +1 more source

Effects of FOXM1 inhibition and ionizing radiation on melanoma cells

, 2018
Vivienne Lee, Lucinda S. McRobb, Vaughan Moutrie, Estavam Santos, Timothy L. Siu   +4 more
openalex   +2 more sources

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth

Advanced Science, EarlyView.
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen, Qiao‐ling Huang, Ming‐zhi Han, Xue‐hui Hong, De‐yi Feng, Lu‐ming Yao, Wen‐bin Hong, Yue Chen, Ya‐ying Huang, Hang‐zi Chen, Qiao Wu   +10 more
wiley   +1 more source