Results 131 to 140 of about 530,239 (305)
Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
Current pharmacotherapy of unresectable malignant melanoma [PDF]
, 2019 Metastatic melanoma continues to set a therapeutic difficulty for health professionals worldwide. In the past decade there have been great advances in melanoma therapy. Multiple new drugs and treatment modalities have been approved for use.
Chaviv, Gal
core
Dermatologic Clinics, 1998 Melanoma vaccines are now an accepted but still experimental treatment for patients who have been rendered clinically free of disease by surgical resection but are at high risk of recurrence and in selected patients with advanced but still limited disease. In general, there seems to be a correlation between the ability of melanoma vaccines to stimulate
openaire +2 more sources
Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light
Advanced Science, EarlyView.Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley +1 more source
Melanoma clinicamente sporadico: valutazione del ruolo di altri parametri oltre l'anamnesi familiare come indicatori di suscettibilità genetica ed applicazione a protocolli di prevenzione mirata al nucleo familiare. [PDF]
, 2003 Melanoma clinicamente sporadico - anamnesi familiare - suscettibilità genetica - protocolli di prevenzione per nucleo ...
MANTELLI M +4 more
core
Dermatology ReportsBackground: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by distinct histopathological and molecular features and often associated with poor prognosis due to its high metastatic potential. While histology,
Italian Melanoma Intergroup
doaj +1 more source
Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source
Advanced Science, EarlyView.This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang +4 more
wiley +1 more source
Immunosurveillance and Melanoma
Journal of Investigative Dermatology, 1989 There is considerable indirect and some direct evidence that immune mechanisms can play an important role in controlling the growth of melanoma. In mice, melanoma can be prevented with vaccines. Consequently, even though naturally occurring immunosurveillance may not be sufficiently potent to prevent melanoma, it is possible that the prophylactic ...
openaire +2 more sources
Correction to “Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma”
Molecular Oncology, EarlyView.
wiley +1 more source