Results 121 to 130 of about 530,239 (305)

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Avaliação in vitro dos efeitos citotóxicos e antimetastáticos de sais de isotiourônio, de n-fenilisotiourônio e de isotiossemicarbazidas em linhagens de melanoma [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.O melanoma é um tipo de câncer de pele extremamente agressivo, devido à alta propensão em produzir ...
Cisilotto, Júlia
core  

07 | Early diagnosis of melanoma in the era of non-invasive imaging: histopathological confirmation of malignancy vs. clinical suspicion. a retrospective study of 2240 patients

Dermatology Reports
Background: Cutaneous melanoma is a leading cause of cancer-related mortality despite accounting for a minority of skin cancers. Early diagnosis is crucial, and dermoscopy has markedly improved diagnostic sensitivity compared with clinical examination ...
Italian Melanoma Intergroup
doaj   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

05 | Revisiting cancer risk associated with the MITF p.e318k variant beyond melanoma

Dermatology Reports
Background: The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele.
Italian Melanoma Intergroup
doaj   +1 more source

Microneedles Mediated Delivery of Nanodiamonds for Quantum Sensing of Free Radicals in Skin Tissue

Advanced Materials Technologies, EarlyView.
Fluorescent nanodiamonds are nanoscale sensors capable of monitoring cellular stress responses. However, to function effectively, they must be delivered into cells or tissues. Here, we demonstrate their application in the skin by developing a dissolvable microneedle platform that dissolves after skin insertion, enabling the delivery of nanodiamonds ...
Siyu Fan, Maria Carmona Lobita, Thea Vedelaar, Yue Zhang, Claudia Reyes‐San‐Martin, Tomás Bauleth‐Ramos, Gésinda Geertsema‐Doornbusch, Han Gao, Mohammad‐Ali Shahbazi, Hélder A. Santos, Romana Schirhagl   +10 more
wiley   +1 more source

04 | Association of a novel TERT polymorphism with poorer survival in male patients with melanoma

Dermatology Reports
Background: In recent years, several genes beyond BRAF have been identified as recurrently mutated in melanoma, including TERT (telomerase reverse transcriptase). While the most extensively studied TERT alterations occur in its promoter region, intron 4
Italian Melanoma Intergroup
doaj   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Role of Methylation in Modulating MAPK Signaling. Implications in Melanoma. Papel de la metilación como modulador de la señalización en MAPK. Implicaciones en melanoma. [PDF]

, 2012
1. General Overview MTAP is a key enzyme in the methionine salvage pathway and controls the levels of methylthioadenosine (MTA). Lost of MTAP, which is frequent in melanoma, results in higher intra and extracellular MTA levels. As MTA is an inhibitor of
Andreu Perez, Pedro Antonio
core  

02 | Melanoma training in primary care: comparing traditional teaching with telemedicine-enhanced education. A review

Dermatology Reports
Background: General practitioners play a crucial role in the early detection and prevention of cutaneous melanoma. However, structured training on skin cancer diagnosis and management is often lacking.
Italian Melanoma Intergroup
doaj   +1 more source