Results 101 to 110 of about 768,066 (299)

Prospective tumour mutation burden and neoantigen profiling predicts immunotherapy response in metastatic melanoma

npj Precision Oncology
Tumour mutation burden (TMB) is a promising biomarker in predicting immunotherapy response, yet its reproducibility across target panels needs to be established. This study assessed the reproducibility of TMB estimates in melanoma using TruSight Oncology
Yizhe Mao, Tuba N. Gide, Nigel G. Maher, Danielle Vignati, Andrea Boutros, Paola Cornejo-Páramo, Alison J. Potter, Matteo S. Carlino, Elizabeth C. Paver, Hazel Burke, Alexander M. Menzies, Serigne N. Lo, Inês Pires da Silva, Richard A. Scolyer, Georgina V. Long, Ismael A. Vergara, James S. Wilmott   +16 more
doaj   +1 more source

21 | Melanoma in situ: long-term outcomes and follow-up strategies based on risk stratification

Dermatology Reports
Background: In recent years, the rising incidence of melanoma in situ (MIS) has drawn increasing attention to treatment and follow-up strategies aimed at reducing the risk of recurrence and new primary melanomas.
Italian Melanoma Intergroup
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

20 | How Covid-19 pandemic influenced the diagnosis of new primary melanoma: a retrospective, multicenter study by the Italian Society of Oncological Surgery

Dermatology Reports
Background: Melanoma is a severe and potentially fatal skin cancer, which is particularly sensitive to delays in diagnosis and treatment (Figure 1). It has been widely demonstrated that the diagnostic delays during COVID-19 pandemic determined higher ...
Italian Melanoma Intergroup
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

GLUT1 expression, lymphocyte distribution and CD3+ T-cell metabolic subsets as predictive markers of response to immunotherapy in advanced melanoma

Journal of Experimental & Clinical Cancer Research
Background Glycolysis, commonly used by malignant tumors for energy production, results in acidification of the tumor microenvironment (TME) through the secretion and accumulation of lactic acid. Acidosis is a potent inhibitor of immune cell function and
Elizabeth C. Paver, Tuba N. Gide, Zarwa Yaseen, Paola Cornejo-Paramo, Peter Ferguson, Nigel G. Maher, Alexander M. Menzies, Matteo S. Carlino, Ines Pires da Silva, Jeff Holst, Georgina V. Long, Richard A. Scolyer, James S. Wilmott   +12 more
doaj   +1 more source

13 | Spatial contexture of tertiary lymphoid structures as a predictor of recurrence in early-stage melanoma

Dermatology Reports
Background: Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells that form in non-lymphoid tissues in response to chronic inflammation, including cancer.
Italian Melanoma Intergroup
doaj   +1 more source

Uveal Melanoma [PDF]

Cancers, 2019
Uveal melanoma (UM) is among the best characterized solid tumors [...]
openaire   +2 more sources

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

30 | Sonidegib for nevoid basal cell carcinoma (Gorlin) syndrome and EADO stage IIb sporadic basal cell carcinomas: a phase II study (SIBLINGS trial)

Dermatology Reports
Background: Nevoid Basal Cell Carcinoma Syndrome (NBCCS), or Gorlin syndrome, is a rare genetic condition characterized by multiple basal cell carcinomas (BCCs). Some sporadic BCC patients present multiple lesions, classified as difficult-to-treat (EADO
Italian Melanoma Intergroup
doaj   +1 more source