Results 101 to 110 of about 593,039 (291)

Stroma-infiltrating T cell spatiotypes define immunotherapy outcomes in adolescent and young adult patients with melanoma

Nature Communications
The biological underpinnings of therapeutic resistance to immune checkpoint inhibitors (ICI) in adolescent and young adult (AYA) melanoma patients are incompletely understood.
Xinyu Bai, Grace H. Attrill, Tuba N. Gide, Peter M. Ferguson, Kazi J. Nahar, Ping Shang, Ismael A. Vergara, Umaimainthan Palendira, Ines Pires da Silva, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, James S. Wilmott, Camelia Quek   +14 more
doaj   +1 more source

30 | Sonidegib for nevoid basal cell carcinoma (Gorlin) syndrome and EADO stage IIb sporadic basal cell carcinomas: a phase II study (SIBLINGS trial)

Dermatology Reports
Background: Nevoid Basal Cell Carcinoma Syndrome (NBCCS), or Gorlin syndrome, is a rare genetic condition characterized by multiple basal cell carcinomas (BCCs). Some sporadic BCC patients present multiple lesions, classified as difficult-to-treat (EADO
Italian Melanoma Intergroup
doaj   +1 more source

‘I am not someone who gets skin cancer’: Risk, time and malignant melanoma [PDF]

, 2013
‘Delay’ is a term used in the cancer literature since the 1930s to describe the period between self-detection of a concerning sign of possible disease and presentation to a health professional.
Heyman, Bob, Topping, Annie, Topping, A.; id_orcid, Nkosana-Nyawata, I., Nkosana-Nyawata, Idah, Heyman, B.   +5 more
core   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Prospective tumour mutation burden and neoantigen profiling predicts immunotherapy response in metastatic melanoma

npj Precision Oncology
Tumour mutation burden (TMB) is a promising biomarker in predicting immunotherapy response, yet its reproducibility across target panels needs to be established. This study assessed the reproducibility of TMB estimates in melanoma using TruSight Oncology
Yizhe Mao, Tuba N. Gide, Nigel G. Maher, Danielle Vignati, Andrea Boutros, Paola Cornejo-Páramo, Alison J. Potter, Matteo S. Carlino, Elizabeth C. Paver, Hazel Burke, Alexander M. Menzies, Serigne N. Lo, Inês Pires da Silva, Richard A. Scolyer, Georgina V. Long, Ismael A. Vergara, James S. Wilmott   +16 more
doaj   +1 more source

32 | Tebentafusp in metastatic uveal melanoma: 3 years of real world data and insights from liquid biopsy

Dermatology Reports
Background: Real world data are needed to optimize the use of Tebentafusp, the first agent improving the overall survival in metastatic uveal melanoma (mUM) patients even if progressive disease (PD) is the best response. Methods: Baseline clinical data,
Italian Melanoma Intergroup
doaj   +1 more source

Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type

, 2017
We have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ.
Tannous, Zeina, Duncan, Lyn M., Lerner, Lisa H., Mihim, Martin C., Flotte, Thomas   +4 more
core   +1 more source

Ultrasound mapping of lymph node and subcutaneous metastases in patients with cutaneous melanoma: Results of a prospective multicenter study [PDF]

, 2006
Background: Ultrasound (sonography, B-mode sonography, ultrasonography) examination improves the sensitivity in more than 25% compared to the clinical palpation, especially after surgery on the regional lymph node area.
Schmid-Wendtner, M. H., Eberle, J. Y., Dill-Muller, D., Kuchelmeister, C., Blum, A., Mauss-Kiefer, V.   +5 more
core   +1 more source

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source

The EORTC Melanoma Group: a comprehensive melanoma research programme by clinicians and scientists. European Organisation for Research and Treatment of Cancer.

, 2002
The EORTC Melanoma Group (MG) was founded in 1969 by both clinicians and scientists from various disciplines and fields of research with a common interest in malignant melanoma.
Keilholz, U., Lienard, D., Eggermont, A.M., Ruiter, D.J., Autier, P., Lehmann, F.   +5 more
core   +1 more source