Results 191 to 200 of about 552,068 (289)

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

A case of "buckshot" metastatic melanoma: A rare and aggressive pattern of cutaneous spread. [PDF]

SAGE Open Med Case Rep
Werpachowski N, Carr C.
europepmc   +1 more source

A Biologically Informed Vision‐Guided Framework for Interpretable T Cell Receptor–Epitope Binding Prediction

Advanced Science, EarlyView.
Integrating hierarchical physicochemical features via a bio‐inspired design, the DAISY framework robustly predicts T‐cell receptor binding, significantly outperforming state‐of‐the‐art models on unseen epitopes. It uniquely offers visual interpretability via Score‐CAM visualizations and profound clinical relevance, correlating with T‐cell expansion ...
Yajing Yuan, Junwei Chen, Yufang Zhang, Yitian Fang, Zhongcheng Fang, Yanyi Chu, Jiayi Li, Chen Zhang, Yuzhe Li, Dongqing Wei   +9 more
wiley   +1 more source

New Strategies in Comprehensive Melanoma Treatment: Applications, Potential, and Challenges of Hydrogels. [PDF]

Int J Nanomedicine
Jin Q, Lin SQ, Xue XJ, Wang LL, Jiang MY, Wang J, Wu SF, Hu YY.   +7 more
europepmc   +1 more source

Melanoma skin cancer detection using MFFN classification approach [PDF]

S Swetha, S. Saranya, M. Devaraju
openalex   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

UHRF1 silencing restrained the malignant phenotype of melanoma cells by inhibiting the HOXA9/HIF-1α axis-mediated glycolysis. [PDF]

Eur J Med Res
Gao Y, Hu C, Jiang S, Lv L, Zhang Y, Cheng Y.   +5 more
europepmc   +1 more source

Pigmentation & Melanoma [PDF]

Journal of Investigative Dermatology, 2015
openaire   +2 more sources

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Multidisciplinary management of urethral melanoma. [PDF]

Urol Case Rep
Rubia Escribano A, González BG, Feliú AH, Martínez BF, Reboiro AM, Navarro Piñeiro A, De Torres IG, Linares Quevedo AI, De La Morena Gallego JM.   +8 more
europepmc   +1 more source