Results 191 to 200 of about 869,771 (326)

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

Human oral malignant melanoma in cell culture [PDF]

, 1966
M. M. Lane Brown, R. Borland, G. W. Milton   +2 more
openalex   +1 more source

Melanoma [PDF]

Journal of the National Comprehensive Cancer Network, 2009
Daniel G, Coit, Robert, Andtbacka, Christopher K, Bichakjian, Raza A, Dilawari, Dominick, Dimaio, Valerie, Guild, Allan C, Halpern, F Stephen, Hodi, Mohammed, Kashani-Sabet, Julie R, Lange, Anne, Lind, Lainie, Martin, Mary C, Martini, Scott K, Pruitt, Merrick I, Ross, Stephen F, Sener, Susan M, Swetter, Kenneth K, Tanabe, John A, Thompson, Vijay, Trisal, Marshall M, Urist, Jeffrey, Weber, Michael K, Wong   +22 more
openaire   +2 more sources

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model

Advanced Science, EarlyView.
A combined optical coherence tomography angiography and fluorescence imaging approach assesses tumor angiogenesis and drug effects in a novel zebrafish cancer model. By analyzing 3D vasculature data, the two imaging methods complement each other to quantify blood flow, vessel structure, and drug efficacy.
Marco Andreana, Ryan Sentosa, Caterina Sturtzel, Martin Pfister, René Werkmeister, Anna Schmitt, David Traver, Rainer Leitgeb, Wolfgang Drexler, Martin Distel, Angelika Unterhuber   +10 more
wiley   +1 more source

PARP inhibitors in melanoma treatment: potential, challenges, and future directions. [PDF]

Front Oncol
Anaeme A, Moussa K, Mansour AN, Nassief G, Ansstas G.   +4 more
europepmc   +1 more source

A rare case of metastatic melanoma in the heart of a horse

, 1917
Hiroshi Morita
openalex   +2 more sources

Primary malignant melanoma of the tongue.A case report and review of the literature [PDF]

, 1965
Jerry J. Principato, Janis V. Sika, Henry C. Sandler   +2 more
openalex   +1 more source

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

Facial Nodular Melanoma Presenting as an Invasive Fungal Infection: A Diagnostic Challenge. [PDF]

Cureus
Schmidt CR, Smith Z, Workman L, Xin V, Davila F, Llenos J.   +5 more
europepmc   +1 more source