Results 201 to 210 of about 528,594 (306)

Acral lentiginous melanoma metastases to the vitreous masquerading as uveitis: A case report. [PDF]

Am J Ophthalmol Case Rep
Chahal R, Ahuja P, Al-Zangana R, Arain Z, Chévez-Barrios P, De la Garza Bravo M, Larkin KL, Gombos DS, Chaudhry AL, Al-Zubidi N.   +9 more
europepmc   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

IL-8 is a potential biomarker for retinal detachment secondary to choroidal melanoma. [PDF]

PeerJ
Xing Z, Zhang X, Yu W, Lei Y, Wang G, Lv H.   +5 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Adjuvant treatment for acral melanoma. [PDF]

J Eur Acad Dermatol Venereol
Komori T, Nakamura Y.
europepmc   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

DHHC3 interferes with antitumor immunity in melanoma cells. [PDF]

Oncotarget
Sharma C, Hwang S, Liu Q, Hemler ME.
europepmc   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Plant-Derived Compounds as Potential Sensitizers to Immunotherapy in Melanoma. [PDF]

Int J Mol Sci
Bătrîna O, Negrea-Ghiulai R, Suciu L, Racoviceanu R, Atyim E, Jorgovan M, Maksimovic T, Mioc A, Trandafirescu C, Șoica C, Mioc M.   +10 more
europepmc   +1 more source

TPC2 regulates proteomic remodeling, bioenergetic phenotypes, and mitochondrial stress adaptation in melanoma. [PDF]

Saudi Pharm J
As Sobeai HM, Hanbashi A, Binobaid L, Alhazzani K, Almufadhili SM, Altuwaijri A, Almousa R, Kamli F, Alhudaithi SS, Alotaibi M, Parrington J.   +10 more
europepmc   +1 more source