Results 191 to 200 of about 768,066 (299)

Pigmentation & Melanoma [PDF]

Journal of Investigative Dermatology, 2015
openaire   +2 more sources

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

The Emerging Melanoma Management: Historical Perspective to Future Directions. [PDF]

Cancers (Basel)
Hui SY, Jain R, Haass NK, Weninger W, Tikoo S, Guo D.   +5 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

SNAT1 (SLC38A1) Is Not the Main Glutamine Transporter in Melanoma, but Controls Metabolism via Glutamine-Dependent Activation of P62 (SQSTM1)/cMYC-Axis. [PDF]

Cancers (Basel)
Lörentz S, Böhme-Schäfer I, König J, Sticht H, Bosserhoff AK.   +4 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Clinical Characteristics at the Diagnosis of New Primary Melanoma in Italy: A Multicenter Retrospective Study Before and After the COVID-19 Pandemic. [PDF]

J Clin Med
Pennacchioli E, Nespoli L, Piazzalunga D, Caliendo V, Rossi P, Clementi M, Mascherini M, Cananzi F, Asero S, Caracò C, Carcoforo P, Del Fiore P, Coppola S, Pellegrini M, Trevisiol C, Picciotto F, Valente MG, Di Raimondo C, Tucceri Cimini I, De Cian F, Laura S, Cavallin F, Buja A, Gallina P, Rastrelli M, SICO (Italian Society of Oncological Surgery) Study Group.   +25 more
europepmc   +1 more source

Nested melanoma [PDF]

Modern Pathology, 2013
openaire   +2 more sources

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Gap Junction-Mediated Communication in Melanoma: From Tumor Progression to Treatment Response. [PDF]

Int J Mol Sci
Massoud J, Ibrahim S, Jensen M, Beary MC, Nafchi B, Springer M, Zucker SN.   +6 more
europepmc   +1 more source