Results 231 to 240 of about 933,936 (328)

A protocol for development of a microsimulation model platform to evaluate the potential benefits, harms, and cost-effectiveness of risk-tailored melanoma screening. [PDF]

PLoS One
McLoughlin KG, Watts CG, Wade S, Smit AK, Soyer HP, Fernandez-Peñas P, Whiteman DC, Guitera P, Reyes-Marcelino G, Canfell K, Cust AE, Caruana M.   +11 more
europepmc   +1 more source

Image 5_Case Report: S100-negative primary anorectal melanoma with elevated Ki67: a case for biology-driven radical resection despite early radiological staging.jpeg

Xiangxiang Ren (21639866), Tianhao Xie (14727424), Litao Liu (2232571), Xiaoshi Jin (15675049), Wei Ma (299083), Jing Sun (141206), Meng Zhang (154027)   +6 more
openalex   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Toll-like Receptor 7/8 Agonists Exert Antitumor Effect in a Mouse Melanoma Model. [PDF]

Medicina (Kaunas)
Isvoranu G, Surcel M, Enciu AM, Munteanu AN, Neagu M, Niculae AM, Chiritoiu G, Munteanu CVA, Chiritoiu-Butnaru M.   +8 more
europepmc   +1 more source

Tyrosinase Overexpression Promotes ATM-Dependent p53 Phosphorylation by Quercetin and Sensitizes Melanoma Cells to Dacarbazine

, 2008
Thilakavathy Thangasamy, Sivanandane Sittadjody, Kirsten H. Limesand, Randy Burd   +3 more
openalex   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Profiling Serum Oxylipin Metabolites Across Melanoma Subtypes and Immunotherapy Responders. [PDF]

Metabolites
Goodman AC, Michel KM, MacBeth ML, Turner JA, Tobin RP, Robinson WA, Couts KL.   +6 more
europepmc   +1 more source

Amelanotic Melanoma of the Oral Cavity.

, 1993
Ling Chu, Aziz ABDUL, Tomihisa Takahashi, Akira Kojima, Takao HIMIYA, Kaoru Kusama, Kazuo Komiyama, Minoru HORI, Mitsuhiko Matsumoto, Hiroshi Tanaka, Itaru Moro   +10 more
openalex   +2 more sources

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source