Results 241 to 250 of about 768,066 (299)

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Challenges in the Diagnosis and Management of Nail Melanocytic Disorders. [PDF]

Clin Cosmet Investig Dermatol
Huang H, Dai XY, Pan LX, Song ZQ, Li L, Liu T.   +5 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Sentinel lymph node status and oncological outcomes of high-risk and low-risk cutaneous primary melanoma. [PDF]

World J Surg Oncol
Mohamed HS, Fadel MG, Wilkinson MJ, Hadjicosta O, Weir J, Power K, Hayes AJ, Smith MJ.   +7 more
europepmc   +1 more source

An Unusual Case of Upper Digestive Bleeding-Metastatic Amelanotic Melanoma: Case Report and Literature Review. [PDF]

Life (Basel)
Dranga M, Cijevschi Prelipcean C, Nedelciuc O, Jucan AE, Sârbu GE, Carmen A, Popa IV, Nemțeanu R, Ciortescu I, Ianole V, Mihai C.   +10 more
europepmc   +1 more source

Associations of Social and Demographic Factors on the Outcomes of Ocular Melanoma and Other Adult Ocular Neoplasms in the United States: A Systematic Review. [PDF]

Cochrane Evid Synth Methods
Shaughnessy D, Joshi V, Dellavalle N, Leslie L, Edwards M, Waxweiler T, Li T, Qureshi R.   +7 more
europepmc   +1 more source

Engineering of the Melanoma Inhibitor of Apoptosis (ML-IAP) Anticancer Peptide Through Comprehensive In Silico Approaches. [PDF]

Hum Mutat
Al-Madhagi HA, Shahab M, Guojun Z, Al-Madhagy G, Bourhia M, Shazly GA, Dauelbait M, Huang Z.   +7 more
europepmc   +1 more source

Oncogenic GPR161 Drives Melanoma Proliferation and Metabolic Activity through TXNIP Inhibition. [PDF]

J Microbiol Biotechnol
Roh Y, Choi J, Hwang JS, Lee YJ, Son T, Kim S, Gu N, Ban HS, Jung E, Kim JS, Han TS.   +10 more
europepmc   +1 more source

AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma. [PDF]

Neoplasia
Paudel R, Goller S, Schwarz S, Meder K, Goebeler M, Schmidt M.   +5 more
europepmc   +1 more source