Results 251 to 260 of about 458,085 (304)
The Ultrastructure of Pigmented Melanoma Cells in Continuous Culture
, 1964 Funan Hu, Robert R. Cardell
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Advanced Science, EarlyView.Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou +9 more
wiley +1 more source
Advanced Science, EarlyView.This study explores the use of ultrasound contrast agents loaded with Stimulator of Interferon Genes (STING) agonists as an approach to activate the body's immune system against cancer. Termed Microbubble‐assisted UltraSound‐guided Immunotherapy of Cancer (MUSIC), this strategy effectively inhibits tumor growth and improves survival in mouse models of ...
Sina Khorsandi +12 more
wiley +1 more source
Advanced Science, EarlyView.A peptide library screening platform has been developed to discover covalent transcription factor inhibitors. It identifies an antagonist cysteine residue, which forms an inhibitory disulphide with cJun C269. Conversion of this cysteine to an electrophile generates an irreversible and selective cJun inhibitor, validating this approach for covalent ...
Andrew Brennan +3 more
wiley +1 more source
Studies of the Antigenicity of Human Malignant Melanoma for Rabbits
, 1966 Inga Silberberg +2 more
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Advanced Science, EarlyView.RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu +9 more
wiley +1 more source
State of Particulate Tyrosinase in Melanoma*
, 1969 I. A. Menon, Herbert F. Haberman
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Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer
Advanced Science, EarlyView.Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng +8 more
wiley +1 more source
Silk Fibroin Nanoparticles for Enhanced Cuproptosis and Immunotherapy in Pancreatic Cancer Treatment
Advanced Science, EarlyView.Cuproptosis can be triggered via intracellular copper overload mediated by elesclomol (ES).Enhancing ES‐Cu's tumor targeting and circulation stability can efficiently induce tumor cuproptosis. TSF@ES‐Cu protect ES‐Cu, target tumors via natural RGD sequences, and release through multi‐responsiveness.
Si Gao +7 more
wiley +1 more source